[9] Niida, Atsushi, et al. "DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway." Oncogene 23.52 (2004): 8520-8526.[10] Zhou, Yu-Xin, et al. "Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Mel...
(e.g., methylation of WIF-1 and APC genes132,133; (2) phosphorylated inactivation of GSK3β134; (3) deregulation of the miRNA for the Wnt pathway;135,136(4) inactivation mutation of CYLD (a negative regulator of both NF-κB and Dvl of the Wnt signaling)5,137; (5) targeting of ...
relevant studies on the treatment of NSCLC with traditional Chinese medicine have received extensive attention and achieved good efficacy. A large number of basic studies have shown that traditional Chinese medicine can play an important role in the proliferation, angiogenesis...
Based on these results, we propose that Dab2 functions as a negative regulator of canonical Wnt signaling by stabilizing the β-catenin degradation complex, which may contribute to its proposed role as a tumor suppressor.S.M. MorrisFred Hutchison Cancer Research CenterJ.A. Cooper...
[9] Niida, Atsushi, et al. "DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway." Oncogene 23.52 (2004): 8520-8526. [10] Zhou, Yu-Xin, et al. "Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Mel...
Wnt was first discovered asInt-1, and then it was found to be a homologous gene of thewinglessgene in Drosophila [11]. Wnt signaling pathways include the canonical Wnt/β-cateninpathway, non-canonical Wnt/planar cell polarity (PCP) pathway and Wnt/Ca2+dependent pathway (Fig.1) [6]. All...
Fig.3 Coop and ISWI are newly discovered factors that regulate the Wnt pathway A: as a newly identified repressive regulator of the Wnt pathway, Coop can compete with beta-Catenin to bind TCF; B: ISWI is the catalytic subunit of the NURF complex and functions as a chromatin remodeling ...
In this regard, Wnt/β-catenin signaling was shown to be a negative regulator of autophagy where β-catenin restrained p62 at the expression level. In fact, accumulation of β-catenin suppresses the p62/SQSTM1 promoter leading to autophagy inhibition [11] (Fig. 6B). Conversely, inhibition of...
Wnt-related genes were expressed at higher levels in endocervical organoids, whereas Wnt-regulator genes were expressed at higher levels in ectocervical organoids. Columns represent individual donors. Colour bar represents z-scored gene expression. i–k, Confocal images of human ectocervical ...
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with glycogen synthase kinase-3β (GSK-3β), β-catenin, adenomatous polyposis coli (APC) gene product, and Dvl, and it regulates GSK-3β-dependent phosphorylation in the complex and the stability of β-catenin. ...