Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless...
Wnt signaling in cancer. Oncogene.Zhan, T.; Rindtorff, N.; Boutros, M. Wnt signaling in cancer. Oncogene 2017, 36, 1461-1473. [CrossRef]ZHAN T,RINDTORFF N,BOUTROS M. Wnt signa⁃ ling in cancer [ J] . Oncogene, 2017, 36 ( 11) : 1461 - 1473.Zhan T, Rindtorff N, Boutros...
2.Nusse R, Clevers H. Wnt/β-Catenin Signaling, Disease, and EmergingTherapeutic Modalities. Cell. 2017 Jun 1;169(6):985-999.3.Ng LF, Kaur P, Bunnag N. WNT Signaling in Disease. Cells. 2019 Aug3;8(8):826.4.Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. ...
3.Ng LF, Kaur P, Bunnag N. WNT Signaling in Disease. Cells. 2019 Aug3;8(8):826. 4.Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017Mar;36(11):1461-1473. 5.Jati S, Sarraf TR, Naskar D, Sen M. Wnt Signaling: Pathogen Incursionand Immune Defense. Front...
Wnt Signaling in Cancer 来自 NCBI 喜欢 0 阅读量: 228 作者: Polakis,P.摘要: Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. From the earliest observation that Wnt overexpression could lead to malignant transformation of mouse mammary tissue to the most ...
3. MacDonald BT, et al. Wnt/beta-cateninsignaling: components, mechanisms, and diseases. Dev Cell. 2009Jul;17(1):9-26.4. T Zhan, etal. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473.5. Theka I, et al. Wnt/β-catenin signaling pathway safeguards epigenetic stability ...
2010年,荷兰阿姆斯特丹大学Jan Paul Medema研究组在Nature Cell Biology发文题为Wnt activity defines colon cancer stem cells and is regulated by the microenvironment,揭开了Wnt信号通路在结肠癌干细胞中的作用,同时也发现结肠癌干细胞中的Wnt信号通路会受到肿瘤微环境的影响【1】。
3. MacDonald BT, et al. Wnt/beta-cateninsignaling: components,mechanisms, and diseases. Dev Cell. 2009Jul;17(1):9-26. 4. T Zhan, etal. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473. 5. Theka I, et al. Wnt/β-catenin signaling pathway safeguards epigenetic stability...
1.Grainger S, Willert K. Mechanisms of Wnt signaling and control. Wiley Interdiscip Rev Syst Biol Med. 2018;10(5):1-22. doi:10.1002/wsbm.1422 2.Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017;36(11):1461-1473. doi:10.1038/onc.2016.304 3.Carballo GB,...
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat Chem Biol. 2018, 14(1): 94-101. >>> 相关产品 JW 55 JW 55 是一种有效的选择性 β-catenin 抑制剂,通过抑制端锚聚合酶 TNKS1 和 TNKS2 发挥作用。 XAV-939 XAV-939 是一种具有选择性的 β-catenin 介导...