Our current study has demonstrated that the Wnt/β-catenin signaling pathway can directly regulate miR-181s expression in HCC. This conclusion is based on the following observations: 1) miR-181 expression was positively associated with β-catenin level in both HCC cell lines and mouse livers wher...
Furthermore, the 6-shogaol-induced increase in FOXO3a expression in liver cancer was notably suppressed by TLR4 or Wnt/β-catenin upregulation. Thus, 6-Shogaol suppresses the progression of liver cancer by mediating Wnt/β-catenin signaling and is a potential agent for the treatment of liver ...
The role of the WNT/beta-catenin signaling in cancer development, especially in colorectal cancer, is now better understood [52,53]. Upregulation of the WNT/beta-catenin pathway via TCF/LEF leads to cell proliferation, EMT, migration and angiogenesis [54–56]. In cancer cells, overactivation ...
The miR-199b-3p/CCDC88A axis regulates the OS cell malignant behaviors via the Wnt/β-catenin pathway and the EMT process in vitro. (A) Inhibition of the expression of miR-199b-3p activates the Wnt/β-catenin signaling pathway and the epithelial–mesenchymal transition process. (B) The miR...
MiR-29b Downregulates Canonical Wnt Signaling by Suppressing Coactivators of β-Catenin in Human Colorectal Cancer Cells The β-catenin/Wnt signaling pathway is activated in many cancers and its constitutive activation has a central role in colorectal cancer pathogenesis. Rec... Maitreyi,Subramanian,Srin...
Kolligs F, Bommer G, Goke B (2002) Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66:131–144 View ArticleKolligs FT, Bommer G, Goke B. Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 2002; 66:131...
Map-kinase signalingEGFRis a transmembrane receptor tyrosine kinase involved in regulating cell proliferation, differentiation and survival. EGFR is actively pursued as a therapeutic target because its aberrant expression or activity has been reported in several cancers. Several studies have reported the ...
Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes. Cui J,Zhou X,Liu Y,et al. Journal of Gastroenterology . 2003Cui J, Zhou X, Liu Y, Tang Z, Romeih M. Wnt signaling in ...
Liver Cancer InstituteJournal of Gastroenterology and HepatologyCui J, Zhou X, Liu Y, et al. Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T- cell factor-4 and glycogen synthase kinase 3-beta genes[J]. J Gastroenterol Hepatol, 2003,18 (3) :...
Cui J, Zhou X, Liu Y, Tang Z, Romeih M: Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes. J Gastroenterol Hepatol 2003, 18: 280–287....