Myant K, Sansom OJ. Wnt Signaling and Colorectal Cancer. Wnt Signaling in Development and Dis- ease: Molecular Mechanisms and Biological Functions. 2014: 357-67.Myant K, Sansom OJ. Wnt signaling and colorectal cancer. In: Hoppler SP, Moon RT, editors. Wnt signaling in development and ...
论文ID 原名:Wnt signaling in colorectal cancer: pathogenic role and therapeutic target 译名:Wnt信号在结直肠癌中的作用:致病作用和治疗靶点 期刊:Molecular Cancer IF:41.444 发表时间:2022年7月 通讯作者:徐海波 通讯作者单位:成...
大家好,今天给大家带来一篇2022年4月发表在Science Advance上的一篇文章“A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer”。本文的通讯作者是哈佛...
The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of vario
Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumorigenesis. Here, we show that environmental glutamine restriction further augments Wnt signaling in APC-mutant intestinal organoids to promote stemness, and leads to adenocarcinoma formation in ...
a. Rho GTPase signaling in the development of colorectal cancer. J. Cell Biochem. 113, 2549–2559 (2012). Article CAS Google Scholar Itoh, K. et al. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat. Med. 5, 221–225 (1999). Article CAS ...
Wnt signaling has recently emerged as a critical pathway in lung carcinogenesis as already demonstrated in many cancers and particularly in colorectal cancer. We critically discuss in this review the individual components of the Wnt pathway and their role in lung cancer development. We propose that ...
2. Wnt signaling and cancer 2.1. Frequent Wnt gene alterations in colorectal cancer The great majority (>90%) of colorectal cancers carry mutations in at least one Wnt signaling pathway gene, such as the adenomatous polyposis coli (APC) and β-catenin (CTNNB1) genes. The APC gene was init...
In non-cancerous cells, transforming growth factor-β (TGFβ) regulates cellular responses primarily through Smad signaling. However, during cancer progression (including colorectal) TGFβ promotes tumoral growth via Smad-independent mechanisms and is involved in crosstalk with various pathways like the ...
valuable insights into acknowledging current opportunities and challenges associated with targeting this signaling pathway in cancer research and treatment. Introduction The Wnt/β-catenin signaling pathway, also referred to as the canonical Wnt signaling pathway, is a conserved and pivotal axis in ...