These Wnt-pathway-active cells constitute a major subpopulation (52%±7.21) of ALDH+ cells that in UC are referred to as precursor-colon cancer stem cells (pCCSC). By clonogenicity assays and serial xenograft transplantations we established the ability of WntpCCSCs to exhibit cancer stem cell...
Selective targeting to the hyperactive β-catenin/T-cell factor pathway in colon cancer cells. Cancer Res. 61, 4445–4449 (2001). CAS PubMed Google Scholar Lipinski, K. S. et al. Optimization of a synthetic β-catenin-dependent promoter for tumor-specific cancer Gene Ther.apy. Mol Ther ...
The Wnt/β-catenin signaling pathway, also referred to as the canonical Wnt signaling pathway, is a conserved and pivotal axis in orchestrating multiple cell-signaling cascades. It plays an indispensable role in a wide range of physiological processes encompassing proliferation, differentiation, apoptosis...
NOTCH1 plays a key role in the Wnt pathway and activation of NOTCH1 is associated with the translocation of β-catenin to the nucleus. 展开 关键词: colon cancer, β -catenin, NOTCH1, NICD1, prognosis DOI: 10.18632/oncotarget.19534 被引量: 2 ...
Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin. However, it has remained a point of controversy whether these mutations are su...
[14] Kang AR, et al. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023 Jul 27. [15] Zhou, et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epit...
[14] Kang AR, et al. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023 Jul 27. [15] Zhou, et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epit...
Involvement of CDX2 in the cross talk between TNF-α and Wnt signaling pathway in the colon cancer cell line Caco-2 2014. Involvement of CDX2 in the cross talk between TNF-alpha and Wnt signaling pathway in the colon cancer cell line Caco-2. Carcinogenesis. 35:1185... Mehmet,Coskun,Ande...
[14] Kang AR, et al. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023 Jul 27. [15] Zhou, et al. Dual regul...
the Wnt/β‑catenin signaling pathway to regulate epithelial‑mesenchymal transition in cancer (...