2010年，荷兰阿姆斯特丹大学Jan Paul Medema研究组在Nature Cell Biology发文题为Wnt activity defines colon cancer stem cells and is regulated by the microenvironment，揭开了Wnt信号通路在结肠癌干细胞中的作用，同时也发现结肠癌干细胞中的Wnt信号通路会受到肿瘤微环境的影响【1】。作为Reproducibility Project: ...
[27] Zhuang, Xueqian,et al."Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1." Nature cell biology 19.10 (2017): 1274-1285. [28] Niu, Jie,et al."DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7...
15. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling intissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.16. Huang SM, et al. Tankyrase inhibition stabilizes axin andantagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-20 17. Gwak ...
Wnt/β-catenin signaling in cancers and targeted therapies Article Open access 30 August 2021 Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Article Open access 03 January 2022 Targeting TGFβ signal transduction for cancer therapy Article Open access 08...
Eli Lilly & Co.DKK1 loaded dendritic cell vaccine(Case Comprehensive Cancer Center)DKK1免疫刺激剂淀粉样变性; 免疫球蛋白a肾病; 意义不明的单克隆丙种球蛋白病;多发性骨髓瘤;阴燃多发性骨髓瘤早期临床1期预防性疫苗The Case Comprehensive Cancer CenterJS015DKK1DKK1抑制剂晚期恶性实体瘤临床申请批准单克隆抗体上...
4.Jia Y, Wang Y, Xie J. The Hedgehog pathway: role in cell differentiation, polarity and proliferation. Arch Toxicol. 2015;89(2):179-191. doi:10.1007/s00204-014-1433-1 5.Bray SJ. Notch signalling in context. Nat Rev Mol Cell Biol. 2016;17(11):722-735. doi:10.1038/nrm.2016....
2010年,荷兰阿姆斯特丹大学Jan Paul Medema研究组在Nature Cell Biology发文题为Wnt activity defines colon cancer stem cells and is regulated by the microenvironment,揭开了Wnt信号通路在结肠癌干细胞中的作用,同时也发现结肠癌干细胞中...
2010年,荷兰阿姆斯特丹大学Jan Paul Medema研究组在Nature Cell Biology发文题为Wnt activity defines colon cancer stem cells and is regulated by the microenvironment,揭开了Wnt信号通路在结肠癌干细胞中的作用,同时也发现结肠癌干细胞中的Wnt信号通路会受到肿瘤微环境的影响【1】。 作为Reproducibility Project: Cance...
cancertherapyThe modular nature of the Wnt pathway provides multiple potential points of intervention to alter its activity. In this chapter we review potential opportunities to inhibit Wnt signalling at various levels, including the synthesis and secretion of Wnt ligands, activation of the Wnt ...
[3] Mariko Shimokawa et al. Visualization and targeting of LGR5+ human colon cancer stem cells. Nature, 2017, 545: 187-192 [4] TAIPALE J, BEACHY P A. The Hedgehog and Wnt signalling pathways in cancer. Nature, 2001, 411: 349-354....