简单来说,wnt/beta-catenin通路是用来调控细胞增殖,细胞极性,以及控制细胞命运的基础通路,能够维持胚胎和组织发育的内稳态(homeostasis)。在这条通路中,外泌糖脂蛋白Wnt作为信号分子,与细胞膜表面受体LRP5/6以及Frizzled结合,激活细胞内通路下游的关键蛋白,GSK3,Axin等,从而调控“中间人” beta-catenin的蛋白分解,进一...
4. Urano T. Wnt-beta-catenin signaling inbone metabolism. Clin Calcium. 2006 Jan;16(1):54-60. PubMed ID: 16397351 5. Souaze F, Viardot-Foucault V, Roullet N,Toy-Miou-Leong M, Gompel A, Bruyneel E, Comperat E, Faux MC, Mareel M, RosteneW, Flejou JF, Gespach C, Forgez P. ...
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12] Ling DJ, et al. MicroRNA-145 inhibits lung cancer cell metastasi...
在没有Wnt信号的情况下,β-catenin被含有AXIN(一种支架蛋白)、APC(adenomatous polyposis coli,结肠腺瘤息肉易感蛋白)、CK1α(casein kinase 1α,酪蛋白激酶1α)、GSK3β(glycogen synthase kinase 3β,糖原合成酶激酶3β)的多亚基复合物结合并调节,这...
在没有Wnt信号的情况下,β-catenin被含有AXIN(一种支架蛋白)、APC(adenomatous polyposis coli,结肠腺瘤息肉易感蛋白)、CK1α(casein kinase 1α,酪蛋白激酶1α)、GSK3β(glycogen synthase kinase 3β,糖原合成酶激酶3β)的多亚基复合物结合并调节,这促进了β-catenin的磷酸化及其与β-TRCP(beta-transducin repea...
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12...
Keywords:non-small cell lung cancer; Wnt/β-catenin signaling pathway; Traditional Chinese Medicine; Mechanism of action; Research progress 肺癌是临床最常见的恶性肿瘤之一,目前已成为全球癌症相关死亡的主要原因,其发病率也呈逐年上升趋势,位居全球第二位[1],对人类的生命健康造成巨大威胁。根据病理分型,可...
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12] Ling DJ, et al. MicroRNA-145 inhibits lung cancer cell metastasi...
11. Varelas X, et al. The Hippo pathway regulatesWnt/beta-catenin signaling. Dev Cell. 2010 Apr 20;18(4):579-91.12. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocyticleukemia cells.Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):...
4. Urano T. Wnt-beta-catenin signaling inbone metabolism. Clin Calcium. 2006 Jan;16(1):54-60. PubMed ID: 16397351 5. Souaze F, Viardot-Foucault V, Roullet N,Toy-Miou-Leong M, Gompel A, Bruyneel E, Comperat E, Faux MC, Mareel M, RosteneW, Flejou JF, Gespach C, Forgez P. ...