DiseaseReceptors, LDLRepressor ProteinsLigandsSignal TransductionActive Transport, Cell NucleusWnt ProteinsFrizzled ReceptorsSignaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-catenin controls embryonic development and adult homeostasis. Here we review recent...
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance. Ferro
Wnt/beta-catenin signaling in development and disease. A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode sm... H Clevers - 《Cell》 被引量: 9010发表: 2006年 Wnt/beta-catenin signaling: ...
Wnt/β-catenin signaling inhibition reduces the expression of miR-181. (A) HT29-APC and HT29-GAL cells were incubated with 100 μM of ZnCL2for different time points (0 hours, 24 hours and 48 hours). Then qRT-PCR analysis of all four mature miR-181s was performed in these cells. (...
Nusse Wnt/beta-catenin signaling and disease Cell, 149 (2012), pp. 1192-1205 View in ScopusGoogle Scholar [28] F.H. Brembeck, M. Rosario, W. Birchmeier Balancing cell adhesion and Wnt signaling, the key role of beta-catenin Curr. Opin. Genet. Dev., 16 (2006), pp. 51-59 View in...
The SOX family of transcription factors have emerged as modulators of canonical Wnt/beta-catenin signaling in diverse development and disease contexts. There are over 20 SOX proteins encoded in the vertebrate genome and recent evidence suggests that many of these can physically interact with beta-cate...
Emerging evidence indicates that Wnt/尾-catenin signaling also c... Y He,H Erika,EJ Yu,... - 《Stem Cells》 被引量: 0发表: 2018年 A Pivotal Role of Androgen Signaling in Notch-Responsive Cells in Prostate Development, Maturation, and Regeneration Androgen signaling is essential for prostate...
Cardamonin inhibits osteogenic differentiation by downregulating Wnt/beta‐catenin signaling and alleviates subchondral osteosclerosis in osteoarthritic mice doi:10.1002/jor.25842Osteoarthritis (OA) is a common degenerative joint disease, and subchondral osteosclerosis is an important pathological change...
Also, TS was shown to decrease cancer cell proliferation through inhibition of PI3K signaling and activation of peroxisome proliferator activated receptor-γ (PPARγ)25,26,27. Thus, we tested the hypothesis that combination therapy involving AD and TS might increase anti-cancer and anti-CSC effects...
we characterized CCDC88A as a direct target of miR-199b-3p. MiR-199b-3p interacted with the 3′UTR of CCDC88A to inhibit the EMT and Wnt/beta-catenin signaling pathway to mediate its tumor-suppressive effect on the proliferation and invasion of OS cells. These findings may be useful for...