Map-kinase signalingEGFRis a transmembrane receptor tyrosine kinase involved in regulating cell proliferation, differentiation and survival. EGFR is actively pursued as a therapeutic target because its aberrant expression or activity has been reported in several cancers. Several studies have reported the ...
Targeting the Wnt/beta-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535. PLoS One. 2014;9(6):e99272. [more] 分子式 C13H10Cl2N2O4S 分子量361.2 CAS号108409-83-2 储存方式﹣20 ℃冷藏长期储存。冰袋运输 溶剂(常温) DMSO83 mg/mL Water<1 ...
Mutations in the adenomatous polyposis coli () gene and K-occur in the majority of human colorectal cancers. Loss of functional APC protein activates the W... Y Araki,S Okamura,S.P. Hussain - 《Cancer Research》 被引量: 898发表: 2003年 WNT/beta-catenin signaling in liver health and dise...
The role of the WNT/beta-catenin signaling in cancer development, especially in colorectal cancer, is now better understood [52,53]. Upregulation of the WNT/beta-catenin pathway via TCF/LEF leads to cell proliferation, EMT, migration and angiogenesis [54–56]. In cancer cells, overactivation ...
3.2. Verification of pharmacotranscriptomic analysis in tumor tissue The Wnt/β-catenin signaling pathway is a central event in CRC, which promotes cancer progression by driving tumor cell proliferation, migration and invasion, and has potential value as a therapeutic target in the treatment of CRC....
PRI-724 and LGK-974 exhibit antitumor properties in NET cell lines. Jin XF, et al. Cancers (Basel). 2020 Feb 4;12(2):345. ICG-001 PRI-724 and ICG-001 are antifibrotic compounds that inhibit Wnt signaling and prevent liver fibrosis. ...
Liver Cancer InstituteMAHMOUD ROMEIHLiver Cancer InstituteJournal of Gastroenterology and HepatologyCui J, Zhou X, Liu Y, Tang Z, Romeih M. Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell fac- tor-4 and glycogen synthase kinase 3-beta ...
Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal Tumorigenesis.doi:10.1159/000066755β-CateninAdenomatous polyposis coliColorectal cancerGastrointestinal cancerT-cell factorWntCancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest...
Wnt signaling in hepatocellular carcinoma: Analysis of mutation and expression of beta-catenin, t-cell factor-4 and glycogen synthase kinase 3-beta genes. J. Gastroenterol. Hepatol. 2003, 18, 280-287. [CrossRef] [PubMed]Cui J,Zhou X,Liu YK,et al.Wnt signaling in hepatocellular carcinoma:...
Purpose Despite the fact that hyper-activation of Wnt/beta-catenin signaling pathway has been seen in many cancers, including liver, colorectal and lung carcinoma, no small molecule inhibitors are available that specifically target this pathway. In this study, we analyzed the impact of dinactin (...