We wonder if the notion of WGS needs clarification when used in discussions with patients. Although each donated DNA sample may have full genome sequencing, it is important for the clinician to explain that only specific segments of the genome, pertaining to the clinical phenotype, will be analyz...
We next performed whole-genome sequencing (WGS) analyses of in vitro and in vivo post-WGD samples. The data showed that the number of acquired mutations in 6-weeks post-WGD RPETP53−/−cells was about 1.8-times higher than in control cells kept in culture for the same amount of time,...
www.nature.com/scientificreports OPEN Use of whole-genome sequencing to trace, control and characterize the regional expansion of received: 03 November 2015 extended-spectrum β-lactamaseaccepted:13January2016 producing ST15 KlebsiellaPublished:11February2016 pneumoniae Kai Zhou1,3, Mariette Lokate1...
2, schizophrenia3,4and autism5. High throughput sequencing (HTS) has been the standard technique for the detection of CNVs over the last decade. Various CNV detection algorithms that use whole genome sequencing (WGS) data have been very successful6,7,8,9,10,11,12with ...
Angiosperms have become the dominant terrestrial plant group by diversifying for ~145 million years into a broad range of environments. During the course of evolution, numerous morphological innovations arose, often preceded by whole genome duplications
the higher the definition of the spatialization will be. The limit is reached when all the tiles of the training WSIs are treated separately (k = 8000) (Supplementary Fig.1). Previous studies31,33,34have demonstrated that a virtual spatialization map (VSM), covering the entire WSI can ...
He presented simplified auricles and no further dysmorphic signs. Via WES we found a de novo frameshift mutation c.670_673dup (p.(Thr225Argfs*4)) in the PCDHA1 gene. We visited patient IV when he was 8 years and 10 months old. He was born at term by cesarean section. During the ...
With the genome sequencing of diploid Rosa chinensis‘Old Blush’, it can presumably become an excellent model plant for functional genomics of ornamental plants [11]. Many gene families with corresponding growth and development need to be examined. In plants, AP2/ERF proteins are profoundly ...