whole-genome whole-population sequencingTheoretical models of ecological specialisation commonly assume that adaptation to one environment leads to fitness reductions (costs) in others. However, experiments often fail to detect such costs. We addressed this conundrum using experimental evolution with ...
DNA sequence analysis refers to the analytical technique that is used to understand the sequence, function, structure of the DNA segment, or the whole of the genome. The DNA sequence is utilized to know the precise order of nucleotides in the DNA segment.Ans...
The advent of genome-wide association studies has accelerated the discovery of novel genetic markers, in particular single nucleotide polymorphisms (SNPs), which are associated with risk for common complex diseases. Technological developments in large-scale genomic studies, such as whole genome sequencing...
KEGG, Kyoto Encyclopedia of Genes and Genomes; WGS, whole genome shotgun. Full size image We have specifically designed LEfSe for biomarker discovery in metagenomic data. We thus summarize our results here from applying the tool to 16S rRNA gene and whole genome shotgun datasets to detect ...
to the direct mutational effects associated with their breakpoints, the "position effect" hypothesis [31]. This latter hypothesis has received so far little attention [32] but the relatively high gene density and compact structure of Drosophila genome (> 90% of euchromatin has functional annotations...
Using genome-wide SNP data, we examined whether known SNPs gleaned from a genome-wide association study could explain the variation observed in LDLc. Four individuals with markedly reduced LDL levels underwent whole exome sequencing. After prioritizing all potential mutations, we identified the most ...