Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea
aDATE:USEby:OCT2011 正在翻译,请等待...[translate] awhile promoting change to a myofibroblast phenotype 当促进对myofibroblast表现型时的变动[translate] aif you pay 500rmb for me, I am ready to pay 150RMB if you pay 500rmb for me, I am ready to pay 150RMB[translate] ...
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Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor 尾 receptor-dependent and -indep... Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease characterized by the overgrowth, hardening, and scarring of lung tissue. ...
Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase. Eur J Pharmacol. 2007;572:12–22. https://doi.org/10.1016/j.ejphar.2007.06.036. Article CAS PubMed Google Scholar Selige J, Hatzelmann A,...
Although fetal fibroblasts do respond to TGF-β, they lack a proliferative and a contractile response and display short-lived myofibroblast differentiation, autocrine response, and collagen up-regulation in comparison with adult fibroblasts. Curiously, prolonged TGF-β activation is associated with ...
et al. Integrity of cell-cell contacts is a critical regulator of TGF-β1-induced epithelial-to-myofibroblast transition: role for β-catenin. Am. J. Pathol. 165, 1955–1967 (2004). Article CAS PubMed PubMed Central Google Scholar Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A....
Wang and collaborators found that OLP fibroblasts significantly expressed more α-smooth muscle actin (SMA) compared to normal ones, indicating the presence of myofibroblast able to produce IL-6, IL-8 and TNF-α in response to Porphyromonas gingivalis LPS [91]. This bacterium, responsible for ...
Increased stiffness of the lung may also promote fibroblast activation and myofibroblast differentiation through mechanotransduction pathways [55,56]. 2.3. Cellular Mediators of Fibrosis Cyclic adenosine monophosphate (cAMP) is a hydrophilic intracellular secondary messenger molecule involved in the regulation ...
Two of them, Pax7 [60] and MyoD [61], are master muscle differentiation regulatory genes; the third is a-SMA, which is known as a myofibroblast cell marker. A Profibrotic Phenotype in Naive and in Fibrotic Lung Myofibroblasts Is Governed by Modulations in Thy-1 Expression and Activation More...