The process of transition from fibroblasts to myofibroblasts is mainly regulated by transforming growth factor (TGF)-β1 (3). In response to TGF-β1, fibroblasts differentiate into myofibroblasts, which contract the wound and aid in the remodeling of the extracellular matrix (ECM) (4). The ...
(1996) Myofibroblasts differentiate from fibroblasts when plated at low density. Proc. Natl. Acad. Sci. USA 93:4219–4223Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci USA. 1996;93(9):4219...
inflammation29, and cardiac fibroblast activation5. Cardiac fibroblasts are the key cellular components of post-MI ventricular fibrosis. Following MI, cardiac fibroblasts differentiate into myofibroblasts, which cause abnormal myocardial stiffness and
During this process, due to the biomechanical and biochemical cues, fibroblasts differentiate to myofibroblasts as the main source of fibrotic tissue [239]. Myofibroblasts enhance ECM production with higher rate of matrix accumulation compared to normal fibroblasts. They are more sensitive to the ...
► In the healing infarct fibroblasts transdifferentiate into myofibroblasts. ► Myofibroblasts secrete extracellular matrix proteins and regulate matrix metabolism. ► As the infarct matures, myofibroblasts become quiescent and undergo apoptosis.
In the mouse lung, fibroblast subtypes have been characterized, one of which (a PDGFRa+Axin2+ subtype) responds by differentiating into myofibroblasts following injury71,72. An analysis of the human lung revealed five fibroblast subtypes, one of which (CTHRC1+) promotes lung fibrosis in COVID-...
These findings provide a strong indication of mast cell/tryptase/PAR2/fibroblast connection influencing the migration of fibroblasts and may also influence differentiation into myofibroblasts. Previous studies have indicated that fibroblasts from IPF lungs exhibit increased PAR2 expression [19]. High ...
In the remodeling heart, cardiac fibroblasts (CFs) differentiate into myofibroblasts (MyoFB), which are the key mediators of the fibrotic response. Additionally, cardiomyocytes are involved by providing pro-fibrotic cues. Nuclear receptor Nur77 is known to reduce cardiac hypertrophy and associated ...
Cardiac fibroblasts get activated in the myocardium mainly by pro-fibrotic factors such as TGF-β122 and differentiate into myofibroblasts, which are characterized by high expression of α-SMA, increased production of extracellular matrix proteins, mainly collagens2, and upregulated expression of the cr...
Besides, when fibroblasts and their surrounding matrix are devoid of fibulin-6, the production of αS MA is reduced resulting in a failure of cells to differentiate from fibroblasts into myofibroblasts after TGF-β stimulation14. In this present study we observed that in the absence of ...