Rehan VK , Torday JS . 2003 . Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation . Cell Biochem Biophys 38 : 239 – 249 .Rehan V, Torday J. Hyperoxia augments pulmonary lipofibroblast-to- myofibroblast transdifferentiation. Cell Biochem Biophys 38: 239 -250, 2003....
Vol.:01345678913CellularandMolecularLifeSciences01875:3943–3961https://doi.org/10.1007/s00018-018-899-4REVIEWFibroblast‑to‑myofibroblasttransitionin bronchialasthmaMarta Michalik1 ·Katarzyna Wójcik‑Pszczoła1 ·Milena Paw1 ·Dawid Wnuk1 ·P
Furthermore, C-188-9 decreased fibroblast-to-myofibroblast differentiation. Finally, TGF-β stimulation of lung fibroblasts resulted in SMAD2/SMAD3-dependent phosphorylation of STAT-3. These findings demonstrate that STAT-3 contributes to the development of lung fibrosis and suggest that STAT-3 may ...
Human bronchial fibroblasts (HBFs) derived from patients diagnosed with asthma display in vitro predestination towards TGF-β-induced fibroblast-to-myofibroblast transition (FMT), a key event in subepithelial fibrosis. As commonly used anti-asthmatic drugs do not reverse the structural changes of the ...
Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition (FMT). However, it remains largely unclear how PD-L1 mediates this process. We found significantly increased PD-L1 in the lun...
Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation. V, Fernandez S, Anfossi R, Diaz-Araya G:Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast- to-Myofibroblast Differentiation. ... Samir,Bolívar,Roxana,... -...
Furthermore, C-188-9 decreased fibroblast-to-myofibroblast differentiation. Finally, TGF-β stimulation of lung fibroblasts resulted in SMAD2/SMAD3-dependent phosphorylation of STAT-3. These findings demonstrate that STAT-3 contributes to the development of lung fibrosis and suggest that STAT-3 may ...
Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important players involved in many biological processes.
Collectively, this study provides insights into the sources of H2O2 in fibroblasts and highlights the novel redox mechanisms underpinning fibroblast-to-myofibroblast differentiation.Marzieh AminzadehanboohiManousos MakridakisDelphine RastiYves CambetKarlHeinz KrauseAntonia Vlahou...
et al. Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. Oncogene 40, 2002–2017 (2021). https://doi.org/10.1038/s41388-021-01663-2 Download citation Received26 April 2020 Revised01 January 2021 Accepted15 ...