Madeja ZbigniewSpringer International PublishingCellular & Molecular Life SciencesMichalik, M.; Wojcik-Pszczoła, K.; Paw, M.; Wnuk, D.; Koczurkiewicz, P.; Sanak, M.; Pe˛kala, E.; Madeja, Z. Fibroblast-to-myofibroblast transition in bronchial asthma. Cell. Mol. Life Sci. 2018. [...
However, how this fibroblast-to-myofibroblast transition (FMT) is regulated and affected by elastin concentration in a three-dimensional (3D) microenvironment has not been investigated. Methods: We developed an insoluble elastin-gradient 3D hydrogel system for long-lasting cell culture and studied the...
Vol.:01345678913CellularandMolecularLifeSciences01875:3943–3961https://doi.org/10.1007/s00018-018-899-4REVIEWFibroblast‑to‑myofibroblasttransitionin bronchialasthmaMarta Michalik1 ·Katarzyna Wójcik‑Pszczoła1 ·Milena Paw1 ·Dawid Wnuk1 ·P
Human bronchial fibroblasts (HBFs) derived from patients diagnosed with asthma display in vitro predestination towards TGF-β-induced fibroblast-to-myofibroblast transition (FMT), a key event in subepithelial fibrosis. As commonly used anti-asthmatic drugs do not reverse the structural changes of the ...
Furthermore, C-188-9 decreased fibroblast-to-myofibroblast differentiation. Finally, TGF-β stimulation of lung fibroblasts resulted in SMAD2/SMAD3-dependent phosphorylation of STAT-3. These findings demonstrate that STAT-3 contributes to the development of lung fibrosis and suggest that STAT-3 may ...
Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important players involved in many biological processes.
Background Fibroblast to myofibroblast transition is believed to contribute to airway remodelling in lung diseases such as asthma and chronic obstructive pulmonary disease. This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast to myofibroblast transition....
Fibroblast-to-myofibroblast transition (FMT) is a key process that promotes IPF pathobiology. Transforming growth factor-beta 1 (TGFβ1), a major pro-fibrogenic cytokine that drives FMT, is a central player in the pathogenesis of IPF [2,3]. Although myofibroblast activation is essential for ...
Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition (FMT). However, it remains largely unclear how PD-L1 mediates this process. We found significantly increased PD-L1 in the lun...
Fenofibrate-induced inhibition of TGF-beta/Smad signalling pathway attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts derived from asthmatic patients Fenofibrate-induced inhibition of TGF-β/Smad signalling pathway attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts deri...