However, how this fibroblast-to-myofibroblast transition (FMT) is regulated and affected by elastin concentration in a three-dimensional (3D) microenvironment has not been investigated. Methods: We developed an insoluble elastin-gradient 3D hydrogel system for long-lasting cell culture and studied the...
Human bronchial fibroblasts (HBFs) derived from patients diagnosed with asthma display in vitro predestination towards TGF-β-induced fibroblast-to-myofibroblast transition (FMT), a key event in subepithelial fibrosis. As commonly used anti-asthmatic drugs do not reverse the structural changes of the ...
Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important players involved in many biological processes. circHIPK3 has been identified as the one of the mo...
Fibroblast-to-myofibroblast transition (FMT) is a key process that promotes IPF pathobiology. Transforming growth factor-beta 1 (TGFβ1), a major pro-fibrogenic cytokine that drives FMT, is a central player in the pathogenesis of IPF [2,3]. Although myofibroblast activation is essential for ...
(FGF) signaling has been implicated in the pathogenesis of lung fibrosis, in particular in the regulation of fibroblast to myofibroblast transition (FMT), ... D Gonalves,C Scribe,P Dellugat,... - 《Revue Des Maladies Respiratoires》 被引量: 0发表: 2024年 Blockage of tubular epithelial to...
A particularly important process associated with the fibrosis of 'asthmatic' airway wall is the transition of local bronchial fibroblasts (HBFs) into a-SMA+ myofibroblasts (FMT) induced by profibrotic cytokines, primarily TGF-b1. Our recent studies have shown that lipid metabolism also play a key...
Myofibroblasts origin mainly from resident fibroblasts via fibroblast-to-myofibroblast transition (FMT) are the dominant collagen-producing cells in pulmonary fibrosis. N-methyladenosine (mA) modification has been implicated in various biological process. However, the role of mA modification in pulmonary ...
Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition (FMT). However, it remains largely unclear how PD-L1 mediates this process. We found significantly increased PD-L1 in the ...
The transition of fibroblasts to myofibroblasts (FMT) represents a pivotal process in wound healing, tissue repair, and fibrotic diseases. This intricate transformation involves dynamic changes in cellular morphology, gene expression, and extracellular matrix remodeling. While extensive...
Mechanistically, fibroblast proliferation and fibroblast-to-myofibroblast transition (FMT) are the two primary causes of cardiac fibrosis. Recent evidence suggests that microRNAs (miRNAs) play a critical role in the pathogenesis of cardiac fibrosis. Therefore, controlling the levels of specific miRNAs ...