In conclusion, the extracellular matrix-localized glycoprotein ADAMTSL2 was upregulated in fibrotic and failing hearts of patients and mice. We identified ADAMTSL2 as a negative regulator of TGFβ in human cardiac fibroblasts, inhibiting myofibroblast differentiation and pro-fibrotic properties....
For instance, YBX1 depletion in mouse macrophages has been associated with augmented tissue damage, myofibroblast activation, and fibrosis. MAFB activity was consistently decreased in the R vs. the NR groups across various tumor-infiltrating immune cell categories, including Macro/Mono, DC, and Mast...
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protein 15 (LRRC15) is associated with poor response to immune check point blockade in PDAC [130]. Targeting TGFβ signaling in myoCAFs might be beneficial for overcoming resistance to immunotherapy as TGFβ signaling plays a critical role in the formation of myoCAFs and restriction of T cell ...
When used as a culture substrate, decellularized ECM derived from fibrotic but not normal lung tissue induces fibrotic traits in reseeded, innocent lung fibroblasts, including collagen production and expression of the contractile fibroblast (myofibroblast) marker α-smooth muscle actin (α-SMA) [13],...
Cancer exosomes trigger fibroblast to myofibroblast differentiation. Can Res. 2010;70(23):9621–30. Article CAS Google Scholar Kim JKT, Lee MS, Mun JY, Ihm C, Kim SA. Exosome cargo reflects TGF-β1-mediated epithelial-to-mesenchymal transition (EMT) status in A549 human lung adenocarcinoma ...
Loss of γ-cytoplasmic actin triggers myofibroblast transition of human epithelial cells Mol. Biol. Cell, 25 (2014), pp. 3133-3146, 10.1091/mbc.E14-03-0815 View in ScopusGoogle Scholar Lenhart and DiNardo, 2015 K.F. Lenhart, S. DiNardo Somatic Cell Encystment Promotes Abscission in Germ...
ITGA3/B1, which binds laminin and also associates with E-cadherin, is required for progression through EMT in lung alveolar epithelial cells, where it integrates beta-catenin and transforming growth factor-β (TGFβ)–SMAD signalling to promote myofibroblast formation and lung fibrosis [40]. ...
To shed light on the discrepant classification of cells as being myofibroblast-like CAFs or pericytes in tumor samples, we reanalyzed a publicly available head and neck squamous cell carcinoma (HNSCC) dataset19and put it in comparison with our dataset. Puram et al.19classified the tumor fibroblas...
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