近日来自德克萨斯大学安德森癌症中心癌症生物学系Raghu Kalluri团队在Cancer Cell杂志上发表题为Type I collagen deletion in aSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer的文章,发现在Kras诱导的自发性小鼠胰腺导管腺癌背景下,肌成纤维细胞中特异性缺失Col1后,免疫抑制增...
myofibroblaststransdifferentiationPulmonary fibrosis is characterized by pronounced collagen deposition and myofibroblast expansion, whose origin and plasticity remain elusive. We utilized a fate-mapping approach to investigate a-smooth muscle actin (aSMA)+ and platelet-derived growth factor receptor a (PDGFRa...