B cells are specialized lymphocytes that play a central role in the humoral component of theadaptive immune response. Naïve B cells are produced from hematopoietic stem cells in the bone marrow and exhibit plasticity as part of the adaptive response with several distinct possible outcomes, includin...
Clonal deletion is the process of neutralizing T and B cells that are reacting to the body's own tissues. This keeps them from...
It may even be that B progenitor cells exist in marrow that are not yet synthesizing Ig but that have made the genetic commitment. If so, the really interesting events are going on inside a black box not yet accessible to the immunologistfs tools of marked antigens and antisera. This ...
rather than collecting host serum to recover a population of polyclonal antibodies, monoclonal antibody generation requires collection of the cells that make antibodies, lymphocytes. Once harvested, lymphocytes are immortalized, established as clonal through limiting dilutions, screened for appropriate expressi...
that low doses of PWM activate mainly bone marrow-derived lymphocytes and that the normal B-lymphocyte population is replaced by leukemic cells in CLL.doi... H Mellstedt,D Pettersson - 《Scandinavian Journal of Immunology》 被引量: 36发表: 2010年 Monoclonal and Oligoclonal Immunoglobulins in th...
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ResponseProduction and Clonal Expansion in a Th1 g Induction in Postdifferentiation IFN-B k T Cell-Intrinsic Requirement for NF-Mark NF- (cid:1) B/Rel transcription factors are linked to innate immune responses and APC activation. Whether and how the induction of NF- (cid:1) B signaling ....
Clonal divergence in Escherichia coli as a result of recombination, not mutation Science, 266 (1994), pp. 1380-1383 CrossrefView in ScopusGoogle Scholar 44 M.C. Maiden, J.A. Bygraves, E. Feil, G. Morelli, J.E. Russell, R. Urwin, Q. Zhang, J. Zhou, K. Zurth, D.A. Caugant...
In contrast, if the B cells are isolated from the blood and used to generate hybridoma via limiting dilution methods, each antibody preparation will be the product of a single clone and will therefore be monoclonal. A main advantage of polyclonal antibodies is that they can provide signal ...
Plating efficiency is used to assess the ability of serum to facilitate cell adherence to solid surfaces for growth. One common assay for this uses A549 human lung carcinoma cells, plated at low density in media supplemented with 5-10% FBS, and monitored for attachment and clonal growth after...