This chapter presents comments on clonal and nonclonal selection and expansion of B cells. Studies carried out in mice, rats, and rabbits have shown that after the injection of an antigen, two population of cells appeared: cells synthesizing and secreting antibodies directed against the antigen ...
In summary, BCRs diversify predominantly in the lymph nodes and only a small selection of B cells expressing these clonal BCR variants are able to perform immunosurveillance across other sites or are temporally persistent. Higher-centrality BCRs are more likely to be seen across a larger number ...
We conclude that muscle-infiltrating B cells undergo selection, somatic hypermutation and clonal diversification in situ during antigen-driven immune responses in patients with IMs, providing insight into the contribution of B cells to the pathological mechanisms of these disorders. 展开 关键词: B cell...
Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of ordered gene rearrangements which must be successfully performed if the cell is to survive. A second selection process occurs during immune responses in which a new antibody repertoire is generated through som...
Affinity maturation of antibodies is achieved by antigen selection of specific B lymphocyte clones expressing membrane immunoglobulin (mIg). A model system was generated to examine antigen:mIg interactions by expressing mIg specific for a hapten, phosphocholine (PC). The murine B lymphoma M12.4 was ...
This is presumably due to the absence of a suitable amplifiable expression system and hence limited protein output compared with other mammalian cells such as Chinese hamster ovary cells. This paper describes a rapid clonal selection method for isolating HEK293 cell lines with high specific ...
This observation advocates that elimination of the TP53-wt population represents a key factor in the clonal selection of TP53-deficient cells, as was also shown in the remission samples. Regarding response duration, the situation is more complex, as, on the one hand, patients reaching CR have ...
Related to clonal expansion:Clonal selection (klōn) n. 1.A group of cells or organisms that are descended from and genetically identical to a single progenitor, such as a bacterial colony whose members arose from a single original cell. ...
aIt establishes the idea that only those cells capable of recognizing an antigen will proliferate while other cells are selected against. Clonal selection operates on both B and T cells. 它建立想法那仅仅那些细胞有能力认出一个抗原将增殖而其他细胞被选择针对。无性系的选择操作 B 和 T 细胞。 [...
Tunable dynamics of B cell selection in gut germinal centres Article 28 October 2020 Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity Article Open access 26 August 2022 Understanding repertoire sequencing data through a multiscale computation...