Again, calling out the unique properties of the ErbB family of RTKs – the kinase activity of these receptors is activated through a unique allosteric mechanism whereby the C-lobe of one kinase domain in the dimer pair (the so called ‘activator’ kinase) physically contacts the N-lobe of t...
酪氨酸激酶受体( tyrosine kinase receptor ) 相关知识点: 试题来源: 解析 酪氨酸激激酶受体:为膜上的一种特殊蛋白质,只有一个跨膜螺旋和一个较短的膜内肽段,当膜外的肽段同相应的化学信号结合时,可以直接激活膜内侧肽段的蛋白激活活性,由此再引发各种细胞内功能的改变。
产品名称:ALK tyrosine kinase receptor ELISA Kit 检测范围:0.312-20 ng/mL 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 操作步骤 1.标准品的稀释:本试剂盒提供原倍标准品一支,用户可按照下列图表在小试管中进行稀释。
Multiple endocrine neoplasia 2B (MEN 2B), a subtype of MEN 2, is caused primarily by a methionine to threonine substitution of residue 918 in the kinase domain of the RET receptor (2B-RET), however the molecular mechanisms that lead to the disease phenotype are unclear. In this study, we...
样本:Leukocyte tyrosine kinase receptor ELISA Kit 检测方法:详见说明书 应用:ELISA 检测限:156-10000 U/mL 货号:BK-F100984 是否进口:是 ELISA试剂盒实验原理: ELISA是以免疫学反应为基础,将抗原、牽9体的特异性反应与酶对底物的高效催化作用相结合起来的一种敏感性很高的试验技术。由于抗原、抗体的反应在一种...
A protein receptor tyrosine kinase (RTK 6) has been isolated from a complementary DNA library of SKOV-3, an epithelial ovarian cancer cell line, using a po... S Laval,R Butler,AN Shelling,... - 《Cell Growth & Differentiation the Molecular Biology Journal of the American Association for ...
Receptor Tyrosine Kinases are single membrane-spanning receptors characterized by the presence of tyrosine kinase activity, which plays a key role in initiating signal transduction processes within cells. AI generated definition based on: Hormones (Third Edition), 2015 ...
Mutations within the ABL1 (tyrosine kinase) domain of the BCR-ABL1 gene are considered to be the most important mechanism of imatinib resistance. Point mutations can directly influence the binding of imatinib to the target molecule, as well as the binding of ATP. Furthermore, point mutations ...
F. Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation. J. Biol. Chem. 282, 28683–28690 (2007). Article CAS PubMed Google Scholar Mathivet, T., Mazot, ...
The epidermal growth factor receptor (EGFR), also called HER1, belongs to ErbB family which is composed of four structure-related RTKs: HER1-4. EGFR is a transmembrane glycoprotein with tyrosine kinase activity in its endo-domain. The activation of EGFR can initiate several crucial signal casca...