David W Fry. Mechanism of action of erbB tyrosine kinase inhibitors[J]. Experimental Cell Research . 2003 (1)Fry, D. W. 2003. Mechanism of action of erbB tyrosine kinase inhibitors. Exp. Cell Res. 284:131-139.Fry D W. Mechanism of action of erbB tyrosine kinase inhibitors[J]....
Combination of a Proteomics Approach and Reengineering of Meso Scale Network Models for Prediction of Mode-of-Action for Tyrosine Kinase Inhibitors In drug discovery, the characterisation of the precise modes of action (MoA) and of unwanted off-target effects of novel molecularly targeted compounds is...
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal function is essential for maintaining normal cell growth and differentiation. However, aberrant activation of PTKs caused by v...
Concerning the mechanism of transmembrane signalling, we like to think that interaction of insulin with the receptor alpha-subunit triggers a conformational change, which is propagated to the beta-subunit and activates it. The active receptor kinase leads then to the phosphorylation of cellular ...
Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Tyrosine kinases are important cellular signaling proteins that have a variety of biological activities including cell proliferation and migration. Multipl... Kristy,J.,GotinkHenk,... - 《Angiogenesis》 被引量: 385发表: ...
The identification of this novel signaling mechanism calls for a critical reevaluation of the mechanisms of action of RTKs and their biological roles. 展开 关键词: CELL-SURFACE-RECEPTOR FGFR1 SIGNALING INFS GAMMA-SECRETASE PROTEIN-KINASE BREAST-CANCER INTRACELLULAR DOMAIN ESTROGEN-RECEPTOR PROSTATE-...
The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound MET receptor in single cell-based assays....
Chan F, Sun C, Perumal M, Nguyen QD, Bavetsias V, McDonald E, Martins V, Wilsher NE, Raynaud FI, Valenti M, Eccles S, Te Poele R, Workman P, Aboagye EO, Linardopoulos S (2007) Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological act...
Aberrant expression of the MET receptor, defined by immunohistochemical (IHC) staining and manifested through amplification, mutation, alternative exon splicing, and abnormal protein metabolism, has led to the development of small-molecule kinase inhibitors (SMKIs) and conventional therapeutic monoclonal ant...
Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action REarranged during Transition (RET) is a tyrosine kinase associated with the development of several malignancies. Identification of RET kinase inhibitors pr... K Takeda,Y Kawamoto,Y Nagasaki,....