酪氨酸激酶受体( tyrosine kinase receptor ) 相关知识点: 试题来源: 解析 酪氨酸激激酶受体:为膜上的一种特殊蛋白质,只有一个跨膜螺旋和一个较短的膜内肽段,当膜外的肽段同相应的化学信号结合时,可以直接激活膜内侧肽段的蛋白激活活性,由此再引发各种细胞内功能的改变。
One of the potential molecular pathways used by cancer cells as an alternative survival system to overcome the blockage of EGFR function is represented by the activation of other tyrosine kinase receptor systems which are not EGFR-related – for example, the insulin-like growth factor (IGF) ...
In general, there are four modes of RTK dimerization which lead to activation of the tyrosine kinase domain. In the first mode, receptor dimerization is completely ligand mediated without any direct contact between the extracellular regions of the two receptors, such as in the case of TrkA (NGF...
RTKs是最大的一类酶联受体,它既是受体,又是酶,能够同配体结合,并将靶蛋白的酪氨酸残基磷酸化。所有的RTKs都是由三个部分组成的:含有配体结合位点的细胞外结构域、单次跨膜的疏水α螺旋区、含有酪氨酸蛋白激酶(RTK)活性的细胞内结构域。 已发现50多种RTKs,主要的几种类型包括:①表皮生长因子受体;②血小板生长...
[名词解释] 受体酪氨酸激酶(receptortyrosinekinase,RTK) 相关知识点: 试题来源: 解析 是细胞膜表面受体的一类,是一类胞质结构域具有蛋白酪氨酸激酶功能的细胞表面受体,这类受体本身兼具受体和酪氨酸激酶两种功能。当这类受体与配体结合后可催化自身或底物蛋白的酪氨酸残基磷酸化,激活后的蛋白质进一步催化细胞内的一...
Receptor Tyrosine Kinases are single membrane-spanning receptors characterized by the presence of tyrosine kinase activity, which plays a key role in initiating signal transduction processes within cells. AI generated definition based on: Hormones (Third Edition), 2015 ...
细胞通讯的基本规律和特点(特异性、级连放大、汇合、发散、交流、终止)•胞外信号分子•受体•细胞内的信号转导分子:信号转导蛋白及第二信使•靶蛋白•信号终止 G蛋白偶联受体信号通路•腺苷酸环化酶信号通路(cAMP)•磷脂酶C信号通路(PI3/DAG)1Chapter5-2Receptortyrosinekinasesignalingpathway2Outline ...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are current standard of care for patients with EGFR mutation and metastatic non-small-cell lung carcinoma (NSCLC), but most patients using EGFR TKIs acquire resistance later. So, overcoming resistance of EGFR TKIs has become...
(4) Tyrosine kinase receptor pathways: tyrosine kinase receptor pathway is one of the most important networks in the intracellular signaling pathways. The signals of most growth factors exert the regulatory function through this signaling pathway. Growth factor receptors have tyrosine kinase activity them...
所属专辑:细胞生物学名词解释 音频列表 1 类病毒(viroid) 54 2018-10 2 受体酪氨酸激酶(receptor tyrosine kinase,RTK) 110 2018-10 3 受体介导的胞吞作用(receptor mediated endocytosis) 113 2018-10 4 受体(receptor) 50 2018-10 5 神经生长因子(nerves growth factor,NGF) ...