The present invention relates to a method for the treatment and diagnosis of immune related diseases, the diseases include those diseases mainly by Th1 or Th2 cells in response to antigen stimulation by the release of cytokine mediated. 本发明进一步涉及基于TCCR基因相对表达水平以及TCCR激动剂或拮抗剂...
Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc. Natl. Acad. Sci. U. S. A. 97, 11439-11444.Ozaki K,Kikly K,Michalovich D,et al.Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain[J].Proc Natl Acad Sci...
cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex ...
A. et al. Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J. Biol. Chem. 286, 33811–33818 (2011). Article CAS PubMed PubMed Central Google Scholar Ho, H. H. & Ivashkiv...
(Smart and Casale 1993). In addition, isolated rat alveolar type II cells release a substantial amount of IL-6, a multifunctional cytokine that can activate inflammatory cells and lymphocytes (Crestaniet al.1994). Alveolar type II cells have also been shown to produce granulocyte macrophage ...
(STING) as a secondary receptor and further stimulates STING-dependent inflammatory cytokine production including type 1 IFNs.109In addition to cytosolic signaling events, type I IFNs can also be produced in response to TLR signaling in macrophages and dendritic cells (DCs). TLR3 and TLR4 sense...
IL-1 Receptor Type I is a cytokine receptor which binds interleukin 1. Anti-IL-1 Receptor Type I antibody is ideal for researchers interested in Immunology, Signal Transduction and Cancer. 应用类型 ELISA,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot, ...
Persistent borna disease virus infection of neonatal rats causes brain regional changes of mrnas for cytokines, cytokine receptor components and neuropeptides Brain Res. Bull., 49 (1999), pp. 441-451 View PDFView articleView in ScopusGoogle Scholar Prather et al., 2009 A.A. Prather, J.E. ...
As ARTS-1 also promotes the shedding of receptors of the TNF (TNFR1) and the type I cytokine receptor superfamilies (IL-6R ), we propose that ARTS-1 plays an important role in modulating innate immune and in?ammatory responses by regulating the shedding of three distinct and structurally ...
A. et al. The cytokine IL-1β activates IFN response factor 3 in human fetal astrocytes in culture. J. Immunol. 174, 3719–3726 (2005). Article CAS PubMed Google Scholar Gonzalez-Navajas, J. M. et al. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like ...