CytokineSims JE, Painter SL, Gow IR. Genomic organization ot the type I and type II IL-1 receptors. Cytokine. 1995; 7 :483–490.Sims JE, Painter SL, Gow IR. Genomic organization of the type I and type II IL-1 receptors. Cytokine 1995; 7: 483-490....
L. et al. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet. 8, e1002552 (2012). This study provided the first RNA sequencing study of cytokine-stressed human β-cells and showed that >50% of...
All type I IFNs bind a common cell-surface receptor, which is known as the type I IFN receptor1–3 (FIG. 1). By contrast, there is only one type II IFN, IFN-γ1–3. The gene that encodes this cytokine is located on chromosome 12 in humans and chromo- some 10 in mice, and ...
68. Gohda T. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol, 2012. 23(3): p. 516-24. 69. Moresco RN.Diabetic nephropathy: traditional to proteomic markers. Clin Chim Acta, 2013. 421: p. 17-30. 70. Goldberg RB. Cytokine and cytokine-...
In addition, cytokines play an important role in regulating immune responses via pro- and anti-inflammatory pathways. Cytokine expression in the brain tissues of autistic patients has been observed and association of marked activation of microglia and astrocyte in the cerebellum with increased cytokine ...
Interferons 12 Acknowledgments Keywords: type I interferons and receptors; purification of human leukocyte interferon α; functional unit of IFN-α; type I interferon (IFN-α/β/ω) receptor; cytokine type 2 receptor family; interferon receptors; signal transduction; therapeutic use of type I ...
Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type...
The innate immune system imparts body’s first line of defense against pathogenic challenges and endogenous stresses through evolving different families of germline-encoded pattern recognition receptors (PRRs) which includes Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), C-type lectin recept...
Type I and type II IFNs activate both common and distinct STAT (signal transducer and activator of transcription) complexes, which regulate the transcription of target genes. In addition to the classical Janus activated kinase (JAK)–STAT-signalling pathways, both type I and type II IFNs activat...
I. Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes 49, 1106–1115 ...