The present invention relates to a method for the treatment and diagnosis of immune related diseases, the diseases include those diseases mainly by Th1 or Th2 cells in response to antigen stimulation by the release of cytokine mediated. 本发明进一步涉及基于TCCR基因相对表达水平以及TCCR激动剂或拮抗剂...
IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 ...
2024年9月25日,Nature同期连发两篇重磅研究Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission和A type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer,揭示了Type-2免疫在维...
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated beta-cell death. Diabetes 60, 2112–2119 (2011). Article CAS PubMed PubMed Central Google Scholar Kenefeck, R. et al. Follicular helper T cell signature in type 1 diabetes...
A. et al. The cytokine IL-1β activates IFN response factor 3 in human fetal astrocytes in culture. J. Immunol. 174, 3719–3726 (2005). Article CAS PubMed Google Scholar Gonzalez-Navajas, J. M. et al. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like ...
a multifunctional cytokine that can activate inflammatory cells and lymphocytes (Crestaniet al.1994). Alveolar type II cells have also been shown to produce granulocyte macrophage colony-stimulating factor,monocytechemoattractant protein-1, and components of the complement system (Paineet al.1993; Simon...
(A) Cytokine secretion by type 1 NKT, Vγ9Vδ2-T cells or a 1:1 mixture thereof after 24-h co-culture with MM.1s.CD1d cells ± 50 nM CD1d-Vδ2 bsTCE (n = 5). (B and C) Specific lysis of MOLM-13 (B, n = 4), NOMO-1 (B, n = 4), and CCRF-CEM (C, n = 3) ...
IItype1receptor(AT1-R),AT2-R,andangiotensinII.TheCNVvolumewassignificantlysuppressedbytreatmentwithanAT1-Rblockertelmisartan,butnotwithanAT2-Rblocker.AT1-RsignalingblockadewithtelmisartaninhibitedvariousinflammatorymechanismsincludingmacrophageinfiltrationandupregulationofVEGF,intercellularadhesionmolecule-1(ICAM-1),...
Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) pathogen that possesses a type III secretion system (T3SS) encoded within the locus of enterocyte effacement (LEE). The LEE is essential for A/E lesion formation and directs the
feature of IL-1 cytokine family members and highlights the extraordinary tight regulation of the biological activity of IL-1. In addition, a second IL-1R chain, the IL-1RII, is both a surface and soluble receptor that lacks a signaling-competent cytosolic domain and therefore functions as an...