The present invention relates to a method for the treatment and diagnosis of immune related diseases, the diseases include those diseases mainly by Th1 or Th2 cells in response to antigen stimulation by the release of cytokine mediated. 本发明进一步涉及基于TCCR基因相对表达水平以及TCCR激动剂或拮抗剂...
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IFN-γ binds a different cell-surface receptor, which is known as the type II IFN receptor7,8 (FIG. 1). IFN-γ is a markedly dif- ferent cytokine than the type I IFNs, but it was origi- nally classified in the IFN family because of its ability to 'interfere' with viral infections...
cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex ...
(ifn-i)-responsive microglial state in the developing somatosensory cortex (postnatal day 5) that is actively engulfing whole neurons. this population expands during cortical remodeling induced by partial whisker deprivation. global or microglial-specific loss of the ifn-i receptor resulted in microglia...
In addition to studies showing the presence of T1 cytokine message in lesional skin, investigators have looked for protein expression, receptor expression, and signs of biologic activity of the primary potential immunoregulatory cytokines IFN-γ and TNF-α. Whereas IFN-γ and its receptor has been ...
Interferons 12 Acknowledgments Keywords: type I interferons and receptors; purification of human leukocyte interferon α; functional unit of IFN-α; type I interferon (IFN-α/β/ω) receptor; cytokine type 2 receptor family; interferon receptors; signal transduction; therapeutic use of type I ...
As ARTS-1 also promotes the shedding of receptors of the TNF (TNFR1) and the type I cytokine receptor superfamilies (IL-6R ), we propose that ARTS-1 plays an important role in modulating innate immune and in?ammatory responses by regulating the shedding of three distinct and structurally ...
feature of IL-1 cytokine family members and highlights the extraordinary tight regulation of the biological activity of IL-1. In addition, a second IL-1R chain, the IL-1RII, is both a surface and soluble receptor that lacks a signaling-competent cytosolic domain and therefore functions as an...
et al. Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling. J. Cell Biol. 209, 579–593 (2015). Article CAS PubMed PubMed Central Google Scholar Babon, J. J. et al. Suppression of cytokine signaling by SOCS3: characterization of the mode ...