thetumorsuppressorLATS1anddestabilizesLATS1bypromotingtheubiquitinationofLATS1miRNA-136-5pandmiRNA-1285-5p;expressionofwhichisdecreasedinhumanbreastcancersandisinverselycorrelatedwiththeprognosisofbreastcancerpatients;aredirectlyinvolvedinsuppressingtheexpressionofHERC4.Insummary;wediscoveramiRNA-HERC4-LATS1pathwaythat...
miRNAs (miRs), a class of non small coding RNAs exert a pivotal role in several biological processes from cell development and differentiation to apoptosis and proliferation. There is a growing body evidence that miRs can act as tumor suppressors or oncogenes and that their expression is tightly...
The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia 2012; 26: 1064-1072.E. Rao, C. Jiang, M. Ji et al., "The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell ...
ErbB pathwayMAPK1Non-small cell lung cancerPAK2miRNA-377BACKGROUND :The ErbB signaling pathway plays important role in the pathogenesis of lung cancer. We explored the role of miRNA-377 as a tumor suppressor in NSCLC through silencing of some genes in the ErbB pathway. METHODS AND RESULTS :...
Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. Cancer Cell. 2015;27(2):298-311.Wegert, J., Ishaque, N., Vardapour, R., et al., 2015. Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA ...