miRNAs (miRs), a class of non small coding RNAs exert a pivotal role in several biological processes from cell development and differentiation to apoptosis and proliferation. There is a growing body evidence that miRs can act as tumor suppressors or oncogenes and that their expression is tightly...
MiRNA-155 has been shown to downregulate the expression of anti-inflammatory proteins in microglia and macrophages, resulting in a pro-inflammatory phenotype. In addition, macrophage phagocytosis of viral particles can also promote the conversion to a pro-inflammatory phenotype. Gao et al. developed ...
Non-coding RNAs are pivotal in numerous cellular functions, eliciting considerable interest in the fields of molecular biology and genetics. They encompass rRNA, tRNA, snRNA, snoRNA, microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA), and other functionally defined RNAs, as...
There are four potential routes for miRNA sorting into exosomes that have been discovered but these mechanisms are not fully understood. The neural sphingomyelinase 2-dependent (nSMase2) pathway is the first, which enhances the production of exosomal miRNA [30]. The heterogeneous nuclear ribonucle...
miRNA: microRNA EMT: epithelial–mesenchymal transition ING2: inhibitor of growth family member 2 3′-UTRs: 3′-untranslated regions FACS: fluorescence activated cell sorter PCNA: proliferating cell nuclear antigen TGF-β: transforming growth factor-β BAX: BCL2 associated X, apoptosis ...
We first confirmed that cZNF215 was unlikely to function as an miRNA sponge. Next, we identified a potential mechanism by which cZNF215 facilitated oxidation-induced inactivation of PTEN and AKTSer473/Thr308 phosphorylation by restraining the interaction between PRDX1 and PTEN. Mechanistically, we ...
proteins andmiRNAto a variety of cells, especially the exocrine secreted by tumor cells. Exosomes derived from breast cancer interact with macrophages through toll-like receptor 2 (TLR2) to trigger the NF-κB signaling pathway, promote the secretion of IL-6,CCL2and TNF-α by M1 macrophages an...
Transcription of the three miRNA miR-34 family members was recently found to be directly regulated by p53. Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2, suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells...
Based on lncRNA-miRNA or lncRNA-mRNA interactions, lncRNA could influence tumor progression by regulating essential gene expressions, such as oncogenes and tumor suppressor genes [11]. Accumulating evidences have revealed that this regulation could reallocate the proportion of composed cells and affect...
miRNA, can promote tumorigenesis and induce cell survival and cisplatin resistance in human ovarian cancer by targeting the 3′-untranslated region (UTR) of phosphatase and tensin homolog (PTEN), which leads to the downregulation of the PTEN protein and upregulation of the Akt pathway13. The ...