miRNAs in apoptosismiRNAs in growthmiRNAs in proliferationCancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers focus on addressing two main questions: "How are oncogenes and/or...
Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth An increased population of CD4+CD25highFoxp3+ regulatory T cells (Tregs) in the tumor-associated microenvironment plays an important role in cancer immune evasion. However, the underlying mechanis...
需要开发适合 TS-miRNA 的药物输送系统;否则,将很难确定 miRNA 作为一种治疗方式的价值。 Enokida H, Yoshino H, Matsushita R, Nakagawa M. The role of microRNAs in bladder cancer. Investig Clin Urol. 2016 Jun;57 Suppl 1(Suppl 1):S60-76. doi: 10.4111/icu.2016.57.S1.S60. Epub 2016 Jun 7....
36. Zhao L, et al. The role of miRNA in ovarian cancer: an overview. Reprod Sci, 2022, 29: 2760-2767. DOI: 10.1007/s43032-02100717-w.
This review summarizes: (i) the current understanding of interactions between miRNAs and their target genes, (ii) recent advances in the regulatory mechanisms that control the expression of genes related to carcinogenesis, and (iii) the role of miRNAs in cancer diagnosis and therapy. 展开 关键词...
35. Zheng H, et al. Advances in circulating microRNAs as diagnostic and prognostic markers for ovarian cancer. Cancer Biol Med, 2013, 10(3): 123-130. 36. Zhao L, et al. The role of miRNA in ovarian cancer: an overview. Reprod Sci, 2022, 29: 2760-2767. DOI: 10.1007/s43032-0210071...
Dick 首次证明了癌 症干细胞的存在,而发展至今,在对抗这类"顽固"的细胞的道路上依然存在许多障碍,等待 着科学家们一一解除.(生物通:张迪) 原文检索:GENES & DEVELOPMENT 21:3238-3243, 2007 A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells『Abstract』 上接 P17 页 ...
miRNA has gained increasing interest in recent years, both in research and clinical fields. miRNAs have been found to play an important role in various diseases, particularly cancer. Aberrant miR-424 expression is found in several tumors where they can function as either oncogenes or tumor-...
13.Beach, A.; Zhang, H.G.; Ratajczak, M.Z.; Kakar, S.S. Exosomes: An overview of biogenesis, composition and role in ovarian cancer. J. Ovarian Res. 2014, 7, 14. 14.Chen, X.; Ba, Y.; Ma, L.; Cai, X.; Yin,...
14. Preusse, M., Theis,F.J. and Mueller, N.S. (2016) miTALOS v2: Analyzing Tissue Specific microRNA Function.PLoS One, 11, e0151771. 15. Sur, I. and Taipale, J. (2016) The role of enhancers in cancer.Nat Rev Cancer, 16,483-493....