The present review aimed to summarize the roles of miRNA-122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery....
It is thus a crucial time for clinicians, cancer scientists and immunologists to determine the next steps in shifting cancer treatment towards better cancer control. This Review describes recent advances in our understanding of tumour-associated myeloid cells. These cells remain less studied than T ...
A single kind of miRNA can target hundreds of mRNAs, affecting the expression of many genes that are often involved in the pathway of functional interaction [11]. Rectal cancer accounts for almost 40 % of all CRC cases. According to the literature, there are some differences in miRNA ...
but abnormal immune responses can sometimes cause severe damage to the host [8]. In recent years, with the deepening of the biological research on liver cancer, there has been increasing interest in the relationship between metastatic liver cancer and immune system. Due to its unique anatomical...
of exosome miRNA to a certain extent, but there are still some problems such as poor RNA stability, complex and expensive technology and false positive signal [13]. In addition, precision medicine has made great progress in the medical field. The detection of circulating miRNA(C-miRNA) as ...
In this review, we will summarize different microglial polarization states and provide evidence of M1/M2 activation states in cancer pain and morphine tolerance. We will also point out the potential of using microglia different activation states as therapeutic targets from cancer pain management to ...
Cancer immunotherapy has recently shown promising antitumor effects in various types of tumors. Among all immune checkpoints, the PD-1/PD-L1 pathway plays an important role in the immune evasion of tumor cells, making it a potent target in antitumor immu
Expression of CDK1 has also been found to be increased in bladder cancer cells, parallel with over-expression of the long non-coding RNA (lncRNA) PVT1. Notably, suppression of PVT1 has decreased activity, proliferative potential, colony formation, migratory capacity, and invasiveness of bladder ...
Regulatory mechanisms of the SASP Several cellular regulatory factors such as p38MAPK, Jak2/Stat3, inflammasomes, m-TOR, miRNA, GATA-4, macroH2A1 and ATM have been proven to play roles during the generation of SASP. It is worth noting that the regulation of the SASP appears to be centred ...
in modulating resistance to cancer immunotherapy. Notably, certain circRNAs function as miRNA sponges or interact with proteins, influencing the expression of immune-related genes, including crucial immune checkpoint molecules. This, in turn, shapes the tumor microenvironment and significantly impacts the ...