The present review aimed to summarize the roles of miRNA-122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery.Zhang, Jing...
It is thus a crucial time for clinicians, cancer scientists and immunologists to determine the next steps in shifting cancer treatment towards better cancer control. This Review describes recent advances in our understanding of tumour-associated myeloid cells. These cells remain less studied than T ...
Tumours co-opt myeloid cells to promote cancer growth. This process occurs not only within the local tumour microenvironment but also in various distant body compartments. Myeloid cells can favour or hinder each step of the metastatic cascade. Myeloid cells have a central, yet still largely unexplo...
MiRNA therapeutics based on logic circuits of biological pathways Valeria Boscaino Antonino Fiannaca Alfonso Urso BMC Bioinformatics(2019) miR-214 as a Key Hub that Controls Cancer Networks: Small Player, Multiple Functions Elisa Penna Francesca Orso ...
of exosome miRNA to a certain extent, but there are still some problems such as poor RNA stability, complex and expensive technology and false positive signal [13]. In addition, precision medicine has made great progress in the medical field. The detection of circulating miRNA(C-miRNA) as ...
(miRNA) function, and chromatin architecture modification.7miRNAs, which are considered the key epigenetic mechanisms for the control of expressed genes, provide a novel dimension to the post-transcriptional control of cells involved in bone remodeling by inhibiting mRNA translation.8,9However, the ...
Additionally, this can increase the radiosensitivity of NSCLCs and the IR-induced apoptosis and autophagy rates, which are associated with the inhibition of AKT and PDK1 phosphorylation [166]. PKM2 is targeted by miR-133 as well, and this miRNA is downregulated in radioresistant lung cancer ...
miRNA inside the nucleus. Pre-miRNA goes to the cytoplasm and after a series of interactions, ultimately becomes a mature miRNA that binds to the target mRNA with the help of proteins called argonaute, which causes mRNA instability or translating suppression (Fig.1) [11]. In recent years, ...
22 So far, more than 3% of the genes in humans have been identified as encoding for miRNAs, and approximately 40% to 90% of the human protein-encoding genes are under miRNA-mediated gene regulation.23 Therefore, numerous miRNAs have been found to be involved in the regulation of bone ...
cancer each year [2]. Strikingly, metastatic liver cancer is 18–40 times more common than HCC [3]. In addition to lymph nodes, the liver emerges as one of the organs most vulnerable to metastasis, particularly in cases of colorectal cancer where it is the primary tumor most likely to ...