The MCs consist of two or more than two miRNA encoding genes driven by a single promoter, transcribed together in the same orientation, that are not separated from each other by a transcription unit. Aberrant miRNA clusters expression is reported in breast cancer (BC), exhibiting both pro-tum...
Wu X, Zeng R, Wu S, Zhong J, Yang L, Xu J. Comprehensive expression analysis of miRNA in breast cancer at the miRNA and isomiR levels. Gene 2015;557(2): 195-200.Wu X,Zeng R,Wu S,et al.Comprehensive expression analysis of miRNA in breast cancer at the miRNA and isomiR levels[J...
the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells
北京大学药学院汤新景 & 王倩发表论文:Development of miRNA-based PROTACs targeting Lin28 for breast cancer therapy 题目:基于 miRNA 靶向 Lin28 的蛋白靶向降解嵌合体的用于乳腺癌治疗的研发 杂志:Science Advances 发表时间:2024 年 9 月 关键发现: 研究团队开发了一系列基于 miRNA 的蛋白靶向降解嵌合体(PROTACs...
Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have bee...
生物通报道 来自剑桥大学的科学家们在新研究中发现,称作microRNAs的遗传“微调控器”控制了人体自身免疫系统对抗乳腺癌的能力。相关研究论文“The shaping and functional consequences of the microRNA landscape in breast cancer”发表在5月5日的《自然》(Nature)杂志上。
近日,英国威斯敏斯特大学等单位的研究人员在International Journal of Molecular Sciences杂志发表了题为:MiR-21 is Required for the Epithelial–Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells的研究论文。 该研究发现,在三阴性乳腺癌中,名为miR-2...
参考文献 Rodvold1, Brian Tsui , Kristen Jepsen, Hannah Carter. Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo
The aim of this study was to review the current knowledge about involvement of microRNAs in breast cancer, and their potential in the clinic, published in scientific journals searched in Pubmed/Medline database until March 2014. MicroRNAs (miRNAs) are a family of 21–25 nucleotide small RNAs ...
Because let-7 has been reported to act as a tumor suppressor based on its targeting of several well-known oncogenes (K-Ras, c-Myc, and HMGA2)61,62,63, Lin28 is conversely considered to be an oncogenic factor and has been investigated in diverse human cancers. In breast cancer, Lin28...