Molecular biology The Biological Functions of miR-122 and its Therapeutic Application in Liver Cancer THE OHIO STATE UNIVERSITY Samson T. Jacob HsuShu-haomiR-122, the most abundant liver-specific microRNA (miRNA), is involved in many different biological functions, including cholesterol metabolism, ...
Long noncoding RNA CASC7 is a novel regulator of glycolysis in oesophageal cancer via a miR-143-3p-mediated HK2 signalling pathway Article Open access 26 April 2022 References Pourhoseingholi MA, Vahedi M, Baghestani AR. Burden of gastrointestinal cancer in Asia; an overview. Gastroenterol ...
RMRP, LINC00242, LINC01518, and DANCR have also been reported to silence miR-1-3p in non-small cell lung cancer, gastric cancer, esophageal squamous cell carcinoma, and glioma cells, respectively, promoting the malignant phenotype of tumor cells [29,30,31,32]. In summary, lncRNA is an im...
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate
The aims of this study were to elucidate the basic role of betatrophin and miR-122a in metabolic syndrome and cancer development related metabolic perturbation. Here, we have separated our study into human case-control study and animal model by using the miR-122a-/- mice. On clinical ...
Abnormal glycolysis within TME can strongly impact the hallmarks of cancer and the function and composition of immune cells. For example, regulatory T (Treg) cells utilize lactic acid and promote the nuclear translocation of NFAT1, upregulating PD-1 expression in highly-glycolytic tumors [16]. ...
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tum
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional therapy. Immunotherapy is crucial for treating met
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Thus, a better understanding of molecular aberrations involved in HCC pathogenesis is necessary for developing effective therapy. It is well established that c
Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunol. Res. https://doi.org/10.1158/2326-6066.CIR-20-0070 (2020). Study on the interplay between the tumour matrix and the immune response, and in particular matrix-remodelling effects...