Long noncoding RNA CASC7 is a novel regulator of glycolysis in oesophageal cancer via a miR-143-3p-mediated HK2 signalling pathway Article Open access 26 April 2022 References Pourhoseingholi MA, Vahedi M, Baghestani AR. Burden of gastrointestinal cancer in Asia; an overview. Gastroenterol ...
Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunol. Res. https://doi.org/10.1158/2326-6066.CIR-20-0070 (2020). Study on the interplay between the tumour matrix and the immune response, and in particular matrix-remodelling effects...
C and D The impact of miR-182 promoter hypermethylation and hypomethylation on overall survival (OS, C) and leukemia-free survival (LFS, D) among AML patients. ***P < 0.001; ns: Not significant Full size image miR-182 promoter methylation is a prognostic biomarker for OS and LFS We...
Molecular biology The Biological Functions of miR-122 and its Therapeutic Application in Liver Cancer THE OHIO STATE UNIVERSITY Samson T. Jacob HsuShu-haomiR-122, the most abundant liver-specific microRNA (miRNA), is involved in many different biological functions, including cholesterol metabolism, ...
miR‐122‐5pradiosensitivityCervical cancer is one of the most common gynecological malignancies globally, Unfortunately, radiotherapy and chemotherapy are not effective at treating some cases of this disease, and the 5﹜ear survival rate is only 40%. CDC25A has been shown to induce radio‐...
Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeutic approaches against solid tumors. In this line, the effects of mechanical forces on CSCs such as epithelial-mesenchymal transition, cellular plasticity, etc., the metabolism pathways of CSCs...
This systematic analysis evaluates the cancer burden over time at the global and national levels measured in incidence, mortality, years lived with
The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a hardwired defined entity has evolved our understanding of the func
Abnormal glycolysis within TME can strongly impact the hallmarks of cancer and the function and composition of immune cells. For example, regulatory T (Treg) cells utilize lactic acid and promote the nuclear translocation of NFAT1, upregulating PD-1 expression in highly-glycolytic tumors [16]. ...
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate