还可促进肿瘤细胞的凋亡,在HCC发生,发展过程中发挥抑癌基因样作用.%miR-122, a kind of miRNA specifically expressing in the liver, under physiological conditions is involved in basic life activities such as spermatogenesis, development, phenotype, differentiation, metabolism and cell response of liver ...
相关研究结果于2017年7月20日在线发表在Molecular Cell期刊上,论文标题为“Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer”。论文通信作者为俄亥俄州立大学综合癌症中心病理学系研究员Kalpana Ghoshal和洛克菲勒大学霍华德-休斯医学研究所分子...
肝脏特异性miR_122的分子生物学特性及功能
Liver RNA from mice treated twice weekly for 4 weeks with 50 mg/kg miR-122 ASO or saline was used for a cDNA microarray experiment using GE CodeLink Mouse Whole Genome chips or for TaqMan RT-PCR confirmation of array results. n=5. Shown are key genes related to lipid metabolism ASO是研...
运动诱导的血管新生作为运动促进健康的主要机制之一,有助于改善血液灌注和组织内的营养供应。然而,运动如何促进生理性血管新生仍须确定,来自空军军医大学高峰教授和张星副教授课题组以及西安交通大学刘健康教授和赵琳副教授课题组发表在《运动与...
关键词:肝癌ꎻ微ＲＮＡꎻ细胞周期蛋白Ｇ１ꎻ解整合素￣金属蛋白酶ꎻＷｎｔ/β联蛋白信号通路ꎻ肿瘤相关基因 ＲｅｓｅａｒｃｈＡｄｖａｎｃｅｉｎＥｆｆｅｃｔａｎｄＭｅｃｈａｎｉｓｍｏｆｍｉＲ￣１２２ｉｎＩｎｈｉｂｉｔｉｎｇＨｅｐａｔｏｃｅｌｌｕｌａｒＣａｒｃｉｎｏｍａ ＬＩＭｉｎｇｆｅｎꎬＬＩＮＨ...
Background: Metastatic tumors in the liver are 20 times more common than primary tumors and considered as a leading cause of mortality in several types of cancer. Therefore, making the liver (soil) inhospitable for tumor cells (seeds) to grow will have tremendous effects on outcome of multiple...
借助生物信息学分析预测 miR-122-5p 的下游基因,并通过细胞转染、Western blotting 等实验手段探究 miR-122-5p/PKM2 轴在人正常肝细胞(Human Normal Liver Cells,HLCs)胰岛素抵抗(Insulin Resistance,IR)和糖代谢(Glucose Metabolism,GM)中的作用。 下面来看具体的研究结果:...
in serum before operation. Results The expression of miR-122 in hepatocarcinoma was (30.84±22.56)% of liver tissues，the range of serum AFP level was 38 ~ 1523μg / L, the mean of serum AFP level was (782 ± 446) μg / L, the low expression of miR-122 in stage Ⅲ liver ...
miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression[J]. Nat Commun, 2018,9(1):5321. DOI: 10.1038/s41467-018-07786-7 . 返回引文位置Google Scholar 百度学术 万方数据 [17] 臧文华,黄显章,唐德才,等. 黄芪-莪术联合顺铂诱导肝癌...