为此,在一项新的研究中,来自美国洛克菲勒大学、俄亥俄州立大学和芝加哥大学的研究人员揭示了这种miR-122可能阻止正常的肝细胞变成恶性肿瘤细胞的一种机制。相关研究结果于2017年7月20日在线发表在Molecular Cell期刊上,论文标题为“Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Pa...
还可促进肿瘤细胞的凋亡,在HCC发生,发展过程中发挥抑癌基因样作用.%miR-122, a kind of miRNA specifically expressing in the liver, under physiological conditions is involved in basic life activities such as spermatogenesis, development, phenotype, differentiation, metabolism and cell response of liver ...
关键词 miR122;功能;疾病;丙型肝炎;乙型肝炎;肝细胞性肝癌 中图分类号 R333 microRNAs是一类长度约为22个核苷酸的非 编码单链RNA,广泛存在于各种生物体内。在动物 体内,通常microRNA能够直接参与蛋白质编码基 因的转录后水平调节,microRNAs和靶mRNA的3' ...
肝脏特异性miR_122的分子生物学特性及功能
此外,研究人员发现miR-122-5p增加了损伤周围皮肤组织的毛细血管密度,能够加速小鼠的伤口愈合,提示miR-122-5p在组织修复中的潜力(图4)。 图4 miR-122-5p促进小鼠伤口愈合 研究表明,运动通过上调肝源性细胞外囊泡的 miR-122-5p 促进血...
关键词:miR-122;hr;阳离子氨基酸转运体-1;丙型肝炎病毒;肝细胞肝癌 中图分类号:Q7 2009年生物物理学报 Table1QuantitativeanalysisofmiR-122inRNA extractedfromtissuesandcells.(Quotedandreworked fromreference[9]) SourceofRNA miR-122 (copy/cell) Adultmousetissues: Liver66000 Heart,lung<50 Spleen,kidney<50...
miR-122 is a highly expressed liver microRNA that is activated perinatally and aids in regulating cholesterol metabolism and promoting terminal differentiation of hepatocytes. Disrupting expression of miR-122 can re-activate embryo-expressed adult-silenced genes, ultimately leading to the development of ...
The scientists examined what happens when liver cells lack a molecule called microRNA-122 (miR-122). They found that when the molecule is missing, the liver develops fat deposits, inflammation and tumors that resemble hepatocellular carcinoma (HCC), the most common form of liver cancer. ...
MiR-122Hepatitis B virusHepatitis C virusHepatitis B virus/hepatitis C virus dual infectionHepatitis B virus (HBV) and hepatitis C virus (HCV)infections are the most common causes of chronicliver diseases and hepatocelluar carcinomas. Overthe past few years, the liver-enriched microRNA-122(miR...
in serum before operation. Results The expression of miR-122 in hepatocarcinoma was (30.84±22.56)% of liver tissues，the range of serum AFP level was 38 ~ 1523μg / L, the mean of serum AFP level was (782 ± 446) μg / L, the low expression of miR-122 in stage Ⅲ liver ...