Molecular biology The Biological Functions of miR-122 and its Therapeutic Application in Liver Cancer THE OHIO STATE UNIVERSITY Samson T. Jacob HsuShu-haomiR-122, the most abundant liver-specific microRNA (miRNA), is involved in many different biological functions, including cholesterol metabolism, ...
Long noncoding RNA CASC7 is a novel regulator of glycolysis in oesophageal cancer via a miR-143-3p-mediated HK2 signalling pathway Article Open access 26 April 2022 References Pourhoseingholi MA, Vahedi M, Baghestani AR. Burden of gastrointestinal cancer in Asia; an overview. Gastroenterol ...
Furthermore, we show that ectopic expression of miR-122 and miR-1, a known regulator of G6PD expression coordinately repress G6PD expression in HCC cells. These miRNAs also reduced G6PD activity in HepG2 cells that express relatively high activity of this enzyme. Collectively, this study ...
miR‐212oncogenesisWntCancer is a major health problem worldwide. An increasing number of researchers are studying the diagnosis, therapy and mechanisms underlying the development and progression of cancer. The study of noncoding RNA has attracted a lot of attention in recent years. It was found ...
have a profound impact on tumor cell behavior. Indeed, exposure of tumor cells to elevated, yet physiologically relevant, pressure, using a pressurized cultured system that maintains a constant pH, has been found to increase or decrease cell proliferation, depending on the cancer cell type [51]....
Last, it is worth to mention that some identified microproteins, like NoBody, have not been directly linked with cancer but they regulate fundamental processes that can impact on cancer cells, such as mRNA decay [5]. Nonsense Mediated Decay is a complex process that can be exploited by cance...
Exposing Panc-1 cells to the β2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell ...
regulating biological processes like cancer cell proliferation, apoptosis, migration, and invasion by controlling multiple downstream target genes. miR-124-3p has been found to be involved in the progression of various kidney diseases, including diabetic kidney disease, calcium oxalate kidney stones, acut...
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate (MVA) pathway. Therefore, this ...
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of the International Cancer Gen