有趣的是,在临床预后要好得多的管腔乳腺癌(luminal breast cancer)细胞中,该基因似乎处于一种永久的关闭状态。 《Cell》揭示癌症耐药的根源 西班牙国家癌症研究中心研究员óscar Fernández-Capetillo领导研究小组,与美国国家癌症研究所的研究人员展开合作,在一项新研究中揭示了具有BRCA1和BRCA2突变的肿瘤,对PARP抑制剂药...
[2] Qi Y, et al. A plant immune protein enables broad antitumor response by rescuing microRNA deficiency. Cell. 2022 May 26;185(11): 1888-1904.e24. [3] Xu J, et al. Development of miRNA-based PROTACs targeting Lin28 for breast cancer therapy. Sci Adv. 2024 Sep 20;10(38): eadp0...
Breast cancer (BC), the most prevalent cancer in women, is a heterogenous disease. Despite advancements in BC diagnosis, prognosis, and therapeutics, survival rates have drastically decreased in the metastatic setting. Therefore, BC still remains a medical challenge. The evo...
2024年9月19日,我室汤新景教授研究团队联合王倩博士在学术期刊Science Advances发表了最新研究成果“Development of miRNA-based PROTACs targeting Lin28 for breast cancer therapy”。 MicroRNA(miRNA)是一种被广泛研究的核酸药物靶标和药物候...
来自剑桥大学的科学家们在新研究中发现,称作microRNAs的遗传“微调控器”控制了人体自身免疫系统对抗乳腺癌的能力。相关研究论文“The shaping and functional consequences of the microRNA landscape in breast cancer”发表在5月5日的《自然》(Nature)杂志上。
Wu X,Zeng R,Wu S,et al.Comprehensive expression analysis of miRNA in breast cancer at the miRNA and isomiR levels[J].Gene,2015,557(2):195-200.Wu, X. et al. Comprehensive expression analysis of mirna in breast cancer at the mirna and isomir levels. Gene 557, 195-200 (2015)....
参考文献 Rodvold1, Brian Tsui , Kristen Jepsen, Hannah Carter. Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo
(生物通:张迪) 原文检索:Cell, Vol 131, 1109-1123, 14 December www.ebiotrade.com 第 1 页,共 50 页 下一页 返回 2007 let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells [Abstract] 附:中国走出世界顶级RNAi专家 2005 年 5 月,广州中山大学附属第二医 院(孙逸仙纪念医院)...
近日,一篇题为“Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway”的miRNA调控机制的文章发表在《Acta Pharm Sin B》,该文章的整体实验设计并不...
10.Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. (2008) Endogenous human microRNAs that suppress breast cancer metastasis.Nature451(7175), 147-52.[abstract] 11.Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills...