MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs that play a role in various biological processes essential for cancer progression. This review presents an overview of how hypoxia regulates the expression of multiple miRNAs in the progression of cancer cells.Valencia-Cervantes, Jesús...
, includingcancer.TheTARDNAbindingprotein43(TDP- 43),aRNA/DNAbindingproteinassociatedwithneu- rodegeneration,isinvolvedinmiRNAbiogenesis.Here, wesystematicallyexaminedmiRNAsregulatedbyTDP- 43usingRNA-SeqcoupledwithansiRNA-mediated knockdownapproach.TDP-43knockdownaffectedthe expressionofanumberofmiRNAs.Inaddition,...
Proliferation, migration and invasion Although the role of CAFs-derived exosomes in cancer development is likely dynamic and specific to cancer type, genetics and stage, the CAFs-derived exosomes can affect the proliferation, migration and invasion of cancer cells. Exosomal microRNAs (miRNAs) were sho...
Cancer-associated fibroblast (CAF) secretes extracellular vesicle (EV)-encapsulated microRNAs (miRNAs) which have been underlined great promise for therapeutic target for diseases and cancers. Our study aimed to explore the role of EV-encapsulated miR-10a-5p from CAFs in angiogenesis in cervical ...
MicroRNAs (miRNAs) are small (∼22 nucleotide) non-coding RNAs that regulate a myriad of biological processes and are frequently dysregulated in cancer. Cancer-associated microRNAs have been detected in serum and plasma and hold promise as minimally invasive cancer biomarkers, potentially for assessin...
MicroRNAs (miRNAs) are a class of very small noncoding RNA molecules. Although they are not directly involved in protein translation process, they indirectly regulate production of proteins by targeting different protein-coding genes or messenger RNAs (mRNAs). Several miRNAs are known to have crucial...
TDP-43 knockdown affected the expression of a number of miRNAs. In addition, TDP-43 down-regulation led to alterations in the patterns of different isoforms of miRNAs (isomiRs) and miRNA arm selection, suggesting a previously unknown role of TDP-43 in miRNA processing. A number of TDP-43 ...
1). This article has reviewed the recent existing studies on the mechanisms of adipocytes in the development of BC, including adipokines regulating, metabolic reprogramming, extracellular matrix (ECM) remodeling, microRNAs (miRNAs) and immune cells adjusting. It also emphasized the clinical implication ...
Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis.Herein,we identified the role of ... SL Guo,P Zheng,X Yang,... - 《International Journal of Biological Sciences》 被引量: 237发表: 2011年 MicroRNA-148a suppresses the epit...
Our previous study has found several gastric cancer-associated miRNAs that include miR-17-5p, miR-18a-5p, miR-18b-5p, miR-19a-3p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-31-5p, miR-106a-5p, miR-106b-5p, miR-133b, miR-139-5p, miR-195-5p, miR-340-3p, miR-378a-3p, miR...