Assessment of tumor-associated stroma has shown a reliable prognostic value in recent research. We evaluated the prognostic value of tumor-stroma ratio (TSR) in a large multicenter cohort of nasopharyngeal carcinoma (NPC). We used the conventional hematoxylin and eosin–stained slides of 115 cases ...
Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment. Am. J. Pathol. 172, 179-193 (2008).Koyama H, Kobayashi N, Harada M et al (2008) Significance of tumor-associated stroma in promotion of intratumoral ...
Babak Ehteshami Bejnordi, Maeve Mullooly, Ruth M Pfeiffer, Shaoqi Fan, Pamela M Vacek, Donald L Weaver, Sally Herschorn, Louise A Brinton, Bram van Ginneken, Nico Karssemeijer, et al. Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic ...
During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on Tumor-associated fibroblasts and their matrix as part of...
Background The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. The tumor-associated stroma is marked by increased expression of CD90/THY1. Isolation and characterization of these stromal...
Chemokines such as CCL2, CXCL5, and CXCL8 recruit immature myeloid cells to the tumor stroma [36]. Immature myeloid cells become immunosuppressive MDSC under the combined influence of tumor-derived IL-1β, IL-6, and S100A8-9, as well as IFN-β, IL-4, IL-13, and IL-10 released by ...
TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study. BMC Cancer. 2007;7:156. Article PubMed PubMed Central Google Scholar Forssell J,...
TAMs regulate ECs through exosomes, thus affecting microangiogenesis in the tumor stroma [100]. Angiogenesis in cancer is associated with downregulation of transcription factor E2F2 [103]. In PDAC, M2 macrophage-derived exosomal miR-155-5p and miR-221-5p induce angiogenesis and increase blood vessel...
Anatomically, macrophages are present at high numbers at the margins of mammary tumors with decreasing frequency throughout the stroma moving deeper within the tumor.25Within the tumor mass, macrophages, either individually or in clusters, are commonly found in association with blood vessels and orches...
TAM and other myeloid-derived tumor infiltrating cells are reviewed as pivotal players in the tumor microenvironment; implications to anti-cancer therapy are described. The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dy...