533 cells from 10 GC patients with matched paratumor tissues and blood. Our results show tumor-associated stromal cells (TASCs) have upregulated activity of Wnt signaling and angiogenesis
Tumor-associated macrophages (TAMs) are the most abundant inflammatory infiltrates in the tumor stroma. TAMs promote tumor growth by suppressing immunocompetent cells, including neovascularization and supporting cancer stem cells. In the chapter, we discuss recent efforts in reprogramming or inhibiting tumo...
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. ten F, Jirstrom K, Leandersson K (2012) The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients... Medrek,Catharina - 《Bmc Can...
Examination into the influence of the tumor stroma has begun to elucidate the role of macrophage–adipocyte interactions in breast cancer development and progression.35Elevated body mass index (BMI) is associated with an increased risk of developing hormone receptor-positive breast cancer after menopause...
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. Cell. 2022;185(2):299–310. Article CAS PubMed PubMed Central Google Scholar Halse H, Colebatch AJ, Petrone P, Henderson MA, Mills JK, Snow H, Westwood JA, ...
There is still a lot to know about complexity of individual macrophages and their associated cancer profile. Multiple types of TAMs exist within the tumor in different locations based on its function. TAMs at hypoxic area are responsible for tumorangiogenesis, whereas those at tumor–stroma interface...
The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of...
Importantly, we found that Notch pathway target genes were elevated in the tumor-associated stroma of JAG1 OE bone metastases (Figure S2F) using mouse-specific RT-PCR analysis. These findings indicate that enforced expression of Jagged1 is sufficient to promote osteolytic bone metastasis, ...
Results Tumor-associated stroma undergoes extensive gene expression changes during cancer progression, to a similar extent as that seen in the malignant epithelium. Highly upregulated genes in the tumor-associated stroma include constituents of the extracellular matrix and matrix metalloproteases, and cell...
Neither B7-H4 nor PD-L1 expression in either tumor or stroma was associated with survival outcome in either cohort (Fig. 3). In both cohorts, overall survival (OS) was nearly identical for those with or without elevated B7-H4 expression. Although there was a trend towards worse OS in one...