Tumor associated stromal cells play a critical role on the outcome of the onco- lytic efficacy of conditionally replicative adenoviruses. PLoS One 2009; 4: e5119 [PMID: 19337591 DOI: 10.1371/journal. pone.0005119]Tumor associated stromal cells play a critical role on the outcome of the ...
533 cells from 10 GC patients with matched paratumor tissues and blood. Our results show tumor-associated stromal cells (TASCs) have upregulated activity of Wnt signaling and angiogenesis
Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30–50% of stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like phenotype in advanced cancer, which plays a crucial role in tumor growth, invasion and migration, angiogenesis and immunosuppression....
Tumor-associated macrophages (TAMs) polarization and its regulatory networks. Polarization of TAMs is regulated by multiple microenvironmental cytokines, growth factors, epigenetic regulators, and other signals derived from tumor and stromal cells. Two types of macrophages (M1/M2) secrete different immune ...
Evidence from physical sciences in oncology increasingly suggests that the interplay between the biophysical tumor microenvironment and genetic regulation has significant impact on tumor progression. Especially, tumor cells and the associated stromal cells not only alter their own cytoskeleton and physical pro...
profiles of ER cofactors or to an intense expression signature in tumor-associated stromal cells that is opposite to that of the cancer cells. Nevertheless, those genes that are estrogen-responsive in cell lines and differentially expressed in ER+tumors represent the most promising candidates for ...
profiled breast cancer tissue cell types and the spatial localization of tumor-associated immune and stromal cells [95]. Based on the spatial annotation, the authors found that T cells were mostly located in an area rich in lymphocytes and in an area composed of stromal cells and lymphocytes....
The immune cell infiltration, immune, stromal, and ESTIMATE scores [43], tumor immune dysfunction and exclusion (TIDE) score [44], immunophenoscore (IPS) [45] and associated indicators were calculated using the R package IOBR [26], and their correlations with the LRscore were also evaluated...
Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation. Brown EB (2013) Tumor-associated macrophages and stromal TNF-alpha regulate collagen structure in a breast tumor model as visualized by second harmonic gener...
Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study, using a mouse lymphoma model, we showed that the lymphoma resident MSCs (L-MSCs) are able to confer tumor-promoting property ...