cancerToll‐like receptorsexosomesanti‐tumor therapyinterleukin‐6Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range of physiological events, including organogenesis and maintenance of tissue homeostasis as well as tissue regeneration and repair. Because their current...
On the one hand, MSCs could contribute to the development and progression of cancer through various ways. First, MSCs are able to influence the phenotype of tumor cells by secreted molecules. For instance, it has been reported that the C–C motif chemokine ligand 5 (CCL5) secreted by MSCs ...
Mesenchymal stem/stromal cells (MSCs) have garnered attention for their potential in cancer therapy due to their ability to home to tumor sites. Engineered MSCs have been developed to deliver therapeutic proteins, microRNAs, prodrugs, chemotherapy drugs, and oncolytic viruses directly to the tumor mi...
This meeting will highlight cutting-edge science and provide insight into recent developments towards therapeutic stromal cell targeting in cancer and chronic inflammatory diseases.Topics Include: Development and Differentiation of Stromal Cells Stromal-Immune Cell Interaction Stromal Cells in Tissue ...
cancer cells, while desmin by pericytes [32,33,34]. CAFs’ immunophenotypic heterogeneity may be partially explained by their different precursors, including tissue-resident fibroblasts, mesenchymal stem cells, bone marrow-derived precursors and endothelial cells [35,36,37,38]. Indeed, integrating ...
Recent progress in the research of mesenchymal stromal cells/multipotent stromal cells (MSC) has revealed numerous beneficial innate characteristics, suggesting potential value in an array of cellular therapies. MSC are easily isolated from bone marrow (BM), fat and other tissues, and are readily pro...
seem to restrain cancer development in favourable circumstances, as they could act as antigen presenting cells in a milieu with abundance of proinflammatory cytokines, such as IL-2 [8]. Therefore, the contribution of fibroblasts, CAFs and other stromal cells in HPV-related tumors is still poorly...
Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy. J. Control. Release 147, 154–162 (2010). CAS PubMed Google Scholar Paget, S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev. 8, 98–101 (1989). CAS PubMed ...
(y-axis) where the analysis domain is limited to the cancer cells’ width (x-axis) and length (z-axis); Figs.1C and F show the stresses along the tissue thickness (z-axis) where the analysis domain is limited to the cancer cells’ width (x-axis) and thickness (y-axis). In Figs...
stromal cellstumor microenvironmentMuscle﹊nvasive bladder cancer (MIBC) is one of the common malignant tumors. Patients with MIBC still have high tumor recurrence and progression rates after surgery. Bioinformatics analysis of stromal infiltration‐related genes in the tumor microenvironment (TME) of ...