activity re Here, we report distinct therapeutical benefit for anti-CD19 CD4+CAR T-cell therapy in two models of B-cell malignancy. Using intravital imaging of the bone marrow to quantify killing events in the sensitive tumor model, we established that perforin-dependent killing account for less...
stages of metastasis. BCBM often induces neurological impairments by affecting cognitive and sensory functions and confer a poor prognosis, high mortality, and lack of effective therapy. A comprehensive understanding of tumor-intrinsic properties and drivers of the crosstalk that allows BC cells to infi...
Through blocking the recruitment of leukocytes, PTIR1 facilitates cancer immune escape and tumor-intrinsic resistance to immunotherapeutic treatments. Unlike RIG-I, PTIR1 is capable of binding to the C terminus of UCHL5 and activates its ubiquitinating function, which in turn inhibits immunoproteasome...
Microglia, as intrinsic immunoeffector cells of the central nervous system (CNS), play a very sensitive, crucial role in the response to almost any brain p... G Fleige,C Nolte,M Synowitz,... - 《Neoplasia》 被引量: 269发表: 2001年 Application of hyperthermia induced by superparamagnetic ...
Once iCluster accumulates at tumor sites, the intrinsic tumor extracellular acidity would trigger the discharge of platinum prodrug-conjugated poly(amidoamine) dendrimers (diameter 5 nm). Such a structural alteration greatly facilitates tumor penetration and cell internalization of the therapeutics. The ...
Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity Melanoma treatment is being revolutionized by the Bao,Riyue,Spranger,... - 《Nature》 被引量: 611发表: 2015年 Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota Antibodies targeting CTLA-4 have been succes...
Advanced laryngeal cancer stage IV, pT3, and pT4 cancer specimens, as well as lymph node-positive tumors, were positively associated with elevated intrinsic STING expression in tumor cells (Fisher’s exact test, p = 0.0031, 0.0336, and 0.0371, respectively). Finally, dedifferentiated tumors of ...
BEIJING, April 19 (Xinhua) -- Nanozymes, nanomaterials with intrinsic enzyme-like activities, have been widely used in cancer diagnosis in recent years, but controlling their performance in treating a target tumor cell remains a challenge.
摘要: A hybrid platform, constructed via the surface 鈥渁rmoring鈥of living yeasts by a manganese silicate compound (MS@Yeast), is investigated for combinational cancer treatment. The intrinsic characteris...收藏 引用 批量引用 报错 分享
and combined them to generate a tumor-intrinsic NGFR signature (Fig.4a, Supplementary Fig.4b). Then, we performed RNA sequencing on three matched parental and TR melanoma cell line pairs and determined whether the NGFR signature was enriched in the TR cells, which was indeed the case (Fig.4b...