Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer 2024, Cancer Cell Citation Excerpt : Taken together, these findings demonstrate the existence of ABCA8a+FAP+ CAFs with lipid-rich phenotype in Setd2-deficient pancreatic...
Cell–cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell–cell communications in the ccR
Metabolic reprogramming in PLC cells can also impact the TME through signaling molecules. Chen et al. proposed that sorafenib treatment increases intra-tumoral hypoxia, promoting immunosuppression through the stromal cell-derived factor 1α (SDF1α)-CXCR4 axis-induced Treg cells/M2φ accumulation in ...
Cell-intrinsically, the K27M mutation leads to broad epigenetic dysregulation and thus transformation of a developmentally restricted cell to a tumorigenic stem-like state12,13,14,15,16,17,18. The resulting active chromatin landscape reflects an early oligodendroglial lineage19,20. Single-cell RNA...
The role of the TME in the development of non–cell-autonomous resistance to antineoplastic agents Full size image Non-cell-autonomous mechanisms of drug resistance in tumors Cell-autonomous resistance, which is the “intrinsic” mechanism of resistance, involves the activation of alternative signaling...
[70]. Nevertheless, understanding how tumor intrinsic transcriptomic alterations contribute to the immune cell content of TIME is still not clear because of the enormous excess of cancer cells in the tumor mass. Recently, by investigating immune checkpoints transcriptome profile, researchers uncovered ...
(Fig.3c). Substantial dysregulation of chromatin remodeling complexes and epigenetic regulation was found to be also a striking signature for some of the clones (notably T3 and T4), and has also been documented as a hallmark of CRC and numerous other cancer types30,31,32,33. Taken together,...
Our data suggested YBX1 may contribute to myeloma cells proliferation, as well as immune modulation, which indicate potential roles of YBX1 in regulating both tumor-intrinsic programs and microenvironment remodeling. Notably, our in vitro results indicated that dysregulation of immune genes including ...
Epigenetic changes due to the loss of MLL3 activity in bladder cancer cells result in the dysregulation of genes associated with the DDR and repair. Consequently, these cells impair the repair process of double-stranded DNA breaks through homologous recombination, leading to the accumulation of endoge...
Cell Communication and Signaling(2024) Current and future immunotherapeutic approaches in pancreatic cancer treatment Pooya Farhangnia Hossein Khorramdelazad Ali-Akbar Delbandi Journal of Hematology & Oncology(2024) Progress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microen...