Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effectsmultiple myelomaDNA methyltransferase inhibitorhistone deacetylase inhibitorimmunogenic cell deathcalreticulintype I interferondendritic cellcytotoxic T-cell
Additionally, in colorectal cancer (CRC), SETD2 suppressed WNT signal-mediated tissue regeneration and tumorigenesis, including colony formation, cell proliferation, migration, self-renewal, and stemness, through epigenetic regulation of RNA processing93. Furthermore, the majority of SETD2 mutations ...
Further investigations have explored the abnormal functioning of NK cells in TME. TGF-β has been shown to impair the metabolism of circulating NK cells in metastatic breast cancer patients. Targeting TGF-β and/or GARP could rejuvenate NK cell metabolism and function, marking an essential aim for...
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms We have previously defined divergent responsiveness of two KRAS-mutant cell lines to PD-1/PD-L1 blockade using an orthotopic, immunocompetent mouse model... AJ...
Thus, using the power of CRISPR genetic screening, we identified key epigenetic determinants of cellular plasticity, which lead to both cell intrinsic and extrinsic changes. These epigenetic modifiers also represent a promising class of therapeutic targets for some of the most lethal aspects of tumor...
Cell–cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell–cell communications in the ccRCC (Clear cell renal carcinoma) microenvironment and how...
Altered immune cell composition [30,31,32], innate immune sensing pathways [33, 34], cellular metabolism [35,36,37] and epigenetic factors [6, 38, 39] are involved in modulating the TME. However, the tumor intrinsic mechanisms that target MHC antigen presentation to reprogram the ...
[70]. Nevertheless, understanding how tumor intrinsic transcriptomic alterations contribute to the immune cell content of TIME is still not clear because of the enormous excess of cancer cells in the tumor mass. Recently, by investigating immune checkpoints transcriptome profile, researchers uncovered ...
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been identified. Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid prog
that contains the metastatic profiles of more than 500 cell lines from 21 solid tumor types, detailing the metastatic potential of various cancer cell lines and providing a model for exploring the mechanism of metastasis.85Metmap shows that the intrinsic characteristics of tumor cells are important ...