Special Issue: Epigenetic regulation of cancer progression: Promises and progressAamir Ahmad
Cancer initiation and progression have been recognised for many years to be secondary to the accumulation of genetic mutations which lead to changes in cellular function. While inherited or sporadic mutations may result in the activation of oncogenes or the inactivation of tumour suppressor genes, cha...
This chapter focuses on summarizing the advancement in the research that illustrates epigenetic regulations in critical steps during metastasis that lead to the final stage of cancer progression, in an attempt to lead the field to potential solutions in cancer treatment and therapeutics that may be ...
Hyperglycemia is a risk factor for breast cancer-related morbidity and mortality. Hyperglycemia inducesNeuregulin 1(Nrg1) overexpression in breast cancer, which subsequently promotes tumor progression. However, molecular mechanisms underlying hyperglycemia-inducedNrg1overexpression remain poorly understood. Here,...
Increased epigenetic variation is a predictor of cancer risk and cancer progression; it promotes the adaptation of the tumour tissue to changing environmental cues by continuously re-establishing tumour cell phenotypic heterogeneity. The mechanism of increased epigenetic variation is functionally intertwined ...
His research interests are in nuclear transfer (cloning), animal model preparation, xenogeneic organ reconstruction, imprinted gene regulation and mechanism of early embryonic development. IPS model to differentiate the cancer cell to study the regulation fo cancer progression during cancer development and...
CoQH2 system can inhibit lipid formation and thus inhibit ferroptosis [52] (Fig.3). Evidences in recent years have revealed that ferroptosis is involved in the regulation of cancer, such as GC, glioma, lung squamous cell carcinoma, BRCA-associated breast cancer, BC, and lung cancer (Table2)...
CoQH2 system can inhibit lipid formation and thus inhibit ferroptosis [52] (Fig.3). Evidences in recent years have revealed that ferroptosis is involved in the regulation of cancer, such as GC, glioma, lung squamous cell carcinoma, BRCA-associated breast cancer, BC, and lung cancer (Table2)...
it is unclear whether cancer stem cells share commonalities with normal adult stem cells. In this review, we will focus on recent discoveries of epigenetic regulation in multiple adult stem cell lineages. We will also discuss how epigenetic mechanisms regulate cancer stem cell activity and probe the...
Normal cells express little to no CXCR4; however, dysregulated and aberrant CXCR4 expression has been observed and reported in a plethora of tumors [18], [19], with serious consequences on cancer progression, especially, cancer cell differentiation, proliferation, invasion, metastasis and ...