Epigenetic regulation in can- cer progression. Cell Biosci 2014;4:45.Baxter E, Windloch K, Gannon F, Lee JS. Epigenetic regulation in cancer progression. Cell Biosci. 2014; 4:1.Baxter E, Windloch K, Gannon F, Lee JS. Epigenetic regulation in cancer progression. Cell & Bioscience 2014;...
Cancer initiation and progression have been recognised for many years to be secondary to the accumulation of genetic mutations which lead to changes in cellular function. While inherited or sporadic mutations may result in the activation of oncogenes or the inactivation of tumour suppressor genes, cha...
The spatiotemporal dynamics of chromatin decondensation and subsequent binding of transcriptional machinery1has an important but incompletely understood role in pathogenic transitions in cancer, such as initiation, progression and metastasis2. Epigenetic regulation affects gene expression, lineage determination, ...
His research interests are in nuclear transfer (cloning), animal model preparation, xenogeneic organ reconstruction, imprinted gene regulation and mechanism of early embryonic development. IPS model to differentiate the cancer cell to study the regulation fo cancer progression during cancer development and...
Increased epigenetic variation is a predictor of cancer risk and cancer progression; it promotes the adaptation of the tumour tissue to changing environmental cues by continuously re-establishing tumour cell phenotypic heterogeneity. The mechanism of increased epigenetic variation is functionally intertwined ...
CoQH2 system can inhibit lipid formation and thus inhibit ferroptosis [52] (Fig.3). Evidences in recent years have revealed that ferroptosis is involved in the regulation of cancer, such as GC, glioma, lung squamous cell carcinoma, BRCA-associated breast cancer, BC, and lung cancer (Table2)...
Epigenetic mechanisms may be the main driving force for critical changes in gene expression that are responsible for progression of prostate cancers. The three most extensively characterized mechanisms for epigenetic gene-regulation are (i) changing patterns of DNA methylation, (ii) histone acetylations...
Through the classic study of genetics, much has been learned about the regulation and progression of human disease. Specifically, cancer has been defined as a disease driven by genetic alterations, including mutations in tumor-suppressor genes and oncogenes, as well as chromosomal abnormalities. Howev...
Hyperglycemia is a risk factor for breast cancer-related morbidity and mortality. Hyperglycemia induces Neuregulin 1 (Nrg1) overexpression in breast cancer, which subsequently promotes tumor progression. However, molecular mechanisms underlying hyperglyc
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes. As the common epigenetic regulation mechanisms, DNA methylation, h