In addition, we confirmed that tumor cell-intrinsic MELK inhibition is beneficial in stimulating M1 macrophage polarization, hindering M2 macrophage polarization and inducing CD8 T-cell recruitment, which are dependent on the alteration of CCL2 expression. Importantly, MELK inhibition amplified RT-related...
Tumor cell-intrinsic MELK enhanced CCL2-dependent immunosuppression to exacerbate hepatocarcinogenesis and confer resistance of HCC to radiotherapy Bufu Tang, Jinyu Zhu, Yueli Shi, Yajie Wang, Xiaojie Zhang, Biao Chen, Shiji Fang, Yang Yang, Liyun Zheng, Rongfang Qiu, Qiaoyou Weng...
MELK was enriched in basal-like and triple-negative breast cancers, and there was a significant correlation between MELK RNA expression and intrinsic radio sensitivity of breast cancer cell lines [41]. MELK knockdown endows TNBC cells with radio sensitivity. DNA repair was inhibited by MELK ...
properties of GBM cells derived from the tumor edge and core lesions in alignment with that of the originating tumor’s spatial identity. These findings raised the possibility that cell-intrinsic factors wrest control of spatial identity at an early time-point of tumor development, leading to the...
Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting these cell populations and their associated GBM hallmarks of stemne...
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition. Cell. 2021;184(3):596-614 e14. Article CAS PubMed PubMed Central Google Scholar Wang H, Li S, Wang Q, Jin Z, Shao W, Gao Y, et al. Tumor immunological phenotype signature-based high-...
both sides of the insert at 5 μg/mL. After 12–24 h, plates were fixed with 4% (w/v) paraformaldehyde and cell migration was assessed based on the number of cells that migrated through the insert by crystal violet staining (3 different randomly selected 10× fields in each insert...
Genetic and epigenetic events in the dormant tumor cell are pivotal regulators of the tumor dormancy program. Epigenetic and genetic events are intrinsic and extrinsic cellular responses that manifest in the upregulation and downregulation of genes, as reflected in the phenotypic plasticity of tumor dor...