Cell-intrinsic PD-L1 similarly drove functional TIC generation, canonical TIC gene expression and sensitivity to interferon-γ and rapamycin in human ES2 ovarian cancer cells. Thus, tumor-intrinsic PD-L1 signals promote TIC generation and virulence, possibly by promoting canonical TIC gene expression,...
tumor cell killing (Fig.1a). To assess the role of SHP2 in this process, we treated co-cultured spheroids with SHP099 and found that it decreased tumor cell numbers after 6 days, exclusively in the presence of activated T cells, in a dose-dependent manner (Fig.1a). OVCAR-8 cells were...
KTC1101 has potential to activate tumor immunity through tumor-cell-intrinsic effects and direct T-cell modulation To underline the potential mechanism of KTC1101 in CD8+ and CD4+ T cells infiltration, and reduction of Treg cells, we sought to (i) explore if KTC1101 influences the expression ...
By contrast, set 2 showed enrichment in genes specific to other cell types in the TME, including vascular endothelium and myeloid infiltrate, but did not show enrichmentofgenesforT cell–inflamed cytolytic processes or tumorcell–intrinsic pathways. 相比之下,set 2显示了TME中其他细胞类型特异性基因的...
Altered immune cell composition [30,31,32], innate immune sensing pathways [33, 34], cellular metabolism [35,36,37] and epigenetic factors [6, 38, 39] are involved in modulating the TME. However, the tumor intrinsic mechanisms that target MHC antigen presentation to reprogram the ...
Elevated tumor cell-intrinsic STING expression was positively associated with stage IV (p = 0.0031), pT3, and pT4 laryngeal cancers (p = 0.0336) as well as with higher histological grades (G2 and G3) (p = 0.0204) and lymph node-positive tumors (p = 0.0371). After adjusting for age,...
However, therapy resistance remains intractable, and both tumor cell-intrinsic and -extrinsic mechanisms have been identified. Clinical results of KRASG12C inhibitors suggest that targeting KRAS rewires TME from immune suppression to pro-inflammation, and combination therapy is required to enhance ...
BEIJING, April 19 (Xinhua) -- Nanozymes, nanomaterials with intrinsic enzyme-like activities, have been widely used in cancer diagnosis in recent years, but controlling their performance in treating a target tumor cell remains a challenge.
Cell–cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell–cell communications in the ccRCC (Clear cell renal carcinoma) microenvironment and how...
To our knowledge a tumor cell-intrinsic role of TNFRSF9 in melanoma has not been described yet and should be followed up in functional experiments. We found significant higher levels of TNFRSF9 methylation in BRAF wildtype compared to mutated melanoma. A recent study identified a network of ...