CD68 tumor-associated macrophage marker is not prognostic of clinical outcome in classical Hodgkin lymphoma. Leuk Lymphoma. 2014;55(5):1031-7.Kayal S, Mathur S, Karak A K, et al. CD68 tumor-associated macrophage marker is not prognostic of clinical outcome in classical Hodgkin lymphoma. ...
Examination into the influence of the tumor stroma has begun to elucidate the role of macrophage–adipocyte interactions in breast cancer development and progression.35Elevated body mass index (BMI) is associated with an increased risk of developing hormone receptor-positive breast cancer after menopause...
In GC, ApoE has recently been identified as a potential tumor-associated marker. However, little is known about the effect of external ApoE on tumor cells. Macrophages are the main source of ApoE in the gastrointestinal tract35, indicating the important role of ApoE from macrophages in gastrointe...
Tumor-associated macrophages Macrophages are prototypical BMDCs that have the ability to modifycancer cellbehavior and promotetumor angiogenesisandmetastasis[84,85]. Macrophage has a great adaptability which helps to acquire a different function at different stages of progression. ...
associated muscle atrophy, a key driver of pancreatic cancer cachexia [22]. Ye et al. comprehensively elucidated the crosstalk between macrophages and pancreatic cancer cells and reported that within a macrophage-rich pancreatic cancer microenvironment, cancer cell-derived lactate induces M2 polarization ...
Tumor-associated macrophage Tumor microenvironment Immunotherapy Macrophage heterogeneity 1. Introduction It is well known that mutations in proto-oncogenes or inactivation in tumor suppressor genes contribute to tumorigenesis. For a long time, most cancer studies have focused on these genetic alterations an...
macrophage subtypes which exhibit distinct marker genes as well as vary in morphology and function within the TME co-express M1 and M2 characteristics [12]. The discovery of TAMs further reveals the heterogeneity and functional diversity of macrophages in cancer [13]. These cells are associated ...
CD68 (pan-macrophage marker), MAC387 (polarized towards type 1 macrophages), and CLEVER-1/Stabilin-1 (type 2 macrophages and lymphatic/blood vessels) were detected immunohistochemically. The median follow-up time was 6.0 years. High macrophage counts associated with a higher pT category and ...
TAM tumor-associated macrophage, CCL chemokine ligand, CYP cytochrome P450, CSF colony-stimulating factor, VEGF vascular endothelial growth factor, HIF-1 hypoxia-inducible factors-1 (Created with BioRender.com). Full size image Fig. 2: Exploiting engineered macrophages for glioma therapy. Because of...
Using a pan-cancer atlas to investigate tumour associated macrophages as regulators of immunotherapy response Article Open access 06 July 2024 M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer Article Op...