macrophage-derived IL-12 licenses the tumorigenic properties of natural killer cells, TH1 T cells and immunogenic dendritic cells, and loss of IL-12 production from TAMs subverts the induction of effective innate and adaptive immunity.33,50The TME skews macrophage...
Using the GSEA strategy, we estimated the three subpopulations of macrophages including macrophage M0, M1, and M2 (Fig.2a) in STAD patients. The results of the cellular characterization of the macrophage showed that pro-tumoral M2 macrophages were more enriched in metastatic STAD patients than thos...
KeywordsTumor-associated macrophage-NFkB-Tumor microenvironment-Phenotype-Cytokinesdoi:10.1007/978-90-481-9531-2_6Robin SoperThorsten HagemannSpringer NetherlandsSoper R, Hagemann T (2010) Shaping tumor associated macrophages: the role of NF-kappaB. In: From molecular to modular tumor therapy: the ...
Tumor-associatedmacrophages(TAMs) define a subset of myeloid cells that highly infiltrate solid tumors. Accumulating evidence clearly demonstrates, in various mouse and human malignancies, including colon, breast, lung, and prostate cancer, a strict correlation between increased numbers and/or density of...
5.2Tumor-Associated Macrophage-Based Therapy Macrophages have emerged as critical factors in breast cancer metastasis and thus represent an attractive cancer specific but tumor cell autonomous target for combinational therapy (Panni, Linehan, & DeNardo, 2013). Given the strong dependence ofTNBConEGFRsi...
网络释义 1. 肿瘤相关巨噬细胞 2)肿瘤相关巨噬细胞(Tumor-associated macrophage, TAM):肿瘤微环境中,巨噬细胞的出现往往与某些肿瘤加速进展关 联, … www.docin.com|基于17个网页
Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population Tumor-associated macrophages (TAM) are exposed to multiple microenvironmental cues in tumors, which collaborate to endow these cells with protumoral activi... D Laoui,E ...
Cellular origins and functions of TAMs. As the major primary resource of macrophages, monocytes are generated from hematopoietic stem cells (HSCs) that differentiate into granulocyte-macrophage progenitors (GMPs) and then into monocyte-dendritic cell progenitors (MDPs). Besides, tissue-resident macrophage...
Tumor-associated macrophage Tumor microenvironment Immunotherapy Macrophage heterogeneity 1. Introduction It is well known that mutations in proto-oncogenes or inactivation in tumor suppressor genes contribute to tumorigenesis. For a long time, most cancer studies have focused on these genetic alterations an...
exosomes derived from M1 macrophages have an important role in tumor invasion and migration. Qi et al. [99] studied the role of M1 macrophage-derived exosomal miR-222 in B-cell lymphoma, observing that miR-222 promoted the apoptosis of bone marrow mesenchymal stem cells (BMSCs) by targeting...