Prognostic significance of tumor-associated macrophages: past, present and futureTumor tissues are populated by a multitude of macrophages, highly different in functional activity, localization and morphology. A clear contribution to disease progression has been shown in multiple cancer types, holding ...
Tumor-associated macrophages (TAMs) contribute to hepatocellular carcinoma (HCC) progression. However, the molecular mechanism underlying the infiltration of TAMs into HCC microenvironment is largely unclear. Recent studies have reported that alteration of mitochondrial nucleoid structures induces mitochondrial D...
Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME) and the most abundant population of immune cells infiltrating a tumor. TAMs can largely determine direction of anti-tumor immune response by promoting it or, conversely, contribute to formation of an ...
line GI-101 with high expression of CD133 and CD44 was found to have greater potential to form brain metastases.101The overexpression of the CD44 variant isoform, CD44v6, in CTCs is associated with brain metastasis of small cell lung cancer, which may enhance the invasiveness of the cells by...
Tumor-associated macrophages (TAMs) interact with tumors in their development, growth and metastatic activities. Using a transgenic mouse model that allows for the selective depletion of macrophages we were able to access the macrophage's potential to facilitate metastasis. In the MaFIA (Macrophage Fas...
Recently, it has been found that RT can trigger an influx of myeloid cells[8]; specifically, myeloid-derived tumor-associated macrophages (TAMs), which are resistant to RT[9]. TAMs are the main component of the tumor microenvironment, accounting for 50% of the tumor mass[10]. TAMs are ma...
[5,6]. Macrophages can have a dual impact on cancer by reversibly changing their phenotype in response to external stimuli, thereby suppressing the cytotoxic activity of immune cells or promoting antitumor responses [7]. Accumulation of tumor-associated macrophages (TAMs) in solid tumors is known ...
And first of all, the BRCA2 germline mutation status is typically associated with a hormone receptor-positive breast cancer risk, which I think is widely known. Now, if I’m not mistaken, I think there’s also an increased probability of lobular cancer in BRCA2s. And that’s something ...
(D) Comparable levels of T cells, B cells, tumor-associated macrophages (TAMs), NK cells, dendritic cells, and monocytes/PMNs are observed between the two models. (E) The T cell compartments display significant differences between the two models. Primary UPS tumors contain less CD4 + T...
EBV-associated gastric adenocarcinomas (EBVaGCs) often exhibit better clinical outcomes than EBV negative gastric cancers (GCs), which could be related to their consistent expression of foreign viral antigens. Antigen-presenting cells (APCs) present pept